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The airway epithelial cell plays a central role in coordinating the pulmonary response to injury and inflammation. Here, transforming growth factor-β (TGFβ) activates gene expression programs to induce stem cell-like properties, inhibit expression of differentiated epithelial adhesion proteins and express mesenchymal contractile proteins. This process is(More)
Several intersecting host, vector, and environmental factors have led to a re-emergence of rickettsial diseases such as Mediterranean Spotted Fever (MSF), and Dermacentor spp.-borne necrosis-erythema lymphadenopathy (DEBONEL). Some rickettsiae produce diffuse endothelial infection and systemic microvascular leakage leading in some cases to high morbidity(More)
Although first responders use a wide range of decision-support tools to identify toxic chemicals during emergencies, few studies have analyzed the tasks and contexts in which such tools are used. Here we discuss an in-depth analysis of semi-structured interviews conducted with 20 first responders from two US states. In the first phase of the analysis, we(More)
Although influenza (flu) and respiratory syncytial virus (RSV) infections are extremely common in children under two years and resolve naturally, a subset develop severe disease resulting in hospitalization despite having no identifiable clinical risk factors. However, little is known about inherent host-specific genetic and immune mechanisms in this(More)
Although a majority of 30-day readmissions of hip-fracture (HFx) patients in the elderly are caused by non-surgical complications, little is known about which specific combinations of comorbidities are associated with increased risk of readmission. We therefore used bipartite network analysis to explore the complex associations between 70 comorbidities(More)
Despite the critical importance of decision-support tools used by first responders during toxic chemical emergencies, little is known about the usage and design requirements for such tools. Guided by the results from a qualitative study of 20 first responders from 2 states, we conducted a nationwide survey of first responders to analyze how current(More)
The exponential growth of biomedical data related to complex diseases such as asthma and Alzheimer's far exceeds our cognitive abilities to comprehend it for tasks such as biomarker discovery, pathway identification, and molecular-based phenotyping. Here we begin by discussing the theoretical foundations for the emerging field of visual analytics, with a(More)
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