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IN 1950 Bloom published a paper on the histological grading of mammary tumours and its possible correlation with prognosis in carcinoma of the breast. He was not the first to consider the importance of the histological picture in relation to the course of the disease. In 1893 von Hansemann coined the term " anaplasia " for the histology of those tumours(More)
CONTEXT Severe acute respiratory syndrome (SARS) is a new clinical entity for which no effective therapeutic strategy has been developed. OBJECTIVE To provide preliminary results on the potential therapeutic benefit and tolerability of interferon alfacon-1 plus corticosteroids for SARS. DESIGN, SETTING, AND PATIENTS Open-label study of 22 patients(More)
Severe acute respiratory syndrome (SARS), caused by a novel coronavirus, emerged in early 2003 as a major international health crisis. We report on serum cytokine levels, viral load and clinical parameters over the course of the disease in a cohort of nine adult SARS patients treated with steroids and interferon alfacon-1 at North York General Hospital in(More)
On May 23, 2003, Toronto experienced the second phase of a severe acute respiratory syndrome (SARS) outbreak. Ninety cases were confirmed, and >620 potential cases were managed. More than 9,000 persons had contact with confirmed or potential case-patients; many required quarantine. The main hospital involved during the second outbreak was North York General(More)
OBJECTIVE This study examined findings of severe acute respiratory syndrome (SARS) on chest radiographs and presented a classification scheme using quantitative radiographic data supported by clinical parameters. MATERIALS AND METHODS Three radiologists who were blinded to the identity, diagnosis, treatment protocol, and outcome of each patient(More)
Colonic ischaemia may complicate aortic graft surgery with high mortality from associated colonic necrosis. Loss of the mucosal barrier function due to ischaemia may promote translocation of endotoxins with secondary systemic disseminated coagulation leading to multiple organ failure. Short-chain fatty acids (SCFAs) stimulate the microcirculation in the(More)
Respiratory alkalosis may be defined as a state of altered physio-chemical processes due to the excessive loss of carbon dioxide through overbreathing. Though this condition is usually referred to as the hyper-ventilation syndrome, respiratory alkalosis would be more accurate terminology as hyperventilation may occur as a necessary physiologic requirement(More)