Bryan Wiltgen

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BACKGROUND Exposure to general anaesthesia during critical stages of brain development results in long-lasting cognitive impairment. Co-administration of protective agents could minimize the detrimental effects of anaesthesia. Co-administration of R(+)pramipexole (PPX), a synthetic aminobenzothiazol derivative that restores mitochondrial integrity, prevents(More)
Dynamic time warping (DTW) has been widely used in various pattern recognition and time series data mining applications. However, as examples will illustrate, both the classic DTW and its later alternative, derivative DTW, may fail to align a pair of sequences on their common trends or patterns. Furthermore, the learning capability of any supervised(More)
Background: Both children and adults with autism spectrum disorders (ASD) often perform better on the Raven's Progressive Matrices intelligence test than on multi-domain intelligence tests like the Wechsler scales, whereas typically developing individuals do not show this pattern. Given the strong visual abilities of many individuals with ASD, one(More)
Biologically inspired design perhaps is one of the most important movements in engineering design. The paradigm espouses use of analogies to biology in generating conceptual designs for new technologies. In this paper, we briefly summarize some empirical findings about biologically inspired design, and then develop an information-processing theory of(More)
Sustainable design is as an important movement in design. Biologically inspired design is a major paradigm for sustainable design. In this paper, we analyze a corpus of biologically inspired design projects in terms of sustainability. We then describe a case study of analogical design of a fog harvesting net, and abstract from it the patterns of Hydrophobia(More)
—Biologically inspired design uses cross-domain analogies from biology to engineering to enhance design creativity and innovation. This analogical transfer requires conceptual understanding of biological systems. In this paper, we describe a prototype interactive knowledge-based design environment called DANE for supporting conceptual understanding through(More)