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In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass accrual during growth. Mutations in LRP5 cause the autosomal recessive disorder osteoporosis-pseudoglioma syndrome (OPPG). We find that OPPG carriers have reduced bone mass when(More)
The Sleeping Beauty transposon system, a non-viral, integrating vector that can deliver the alpha-L-iduronidase-encoding gene, is efficient in correcting mucopolysaccharidosis type I in NOD/SCID mice. However, in previous studies we failed to attain reliable long-term alpha-L-iduronidase expression in immunocompetent mice. Here, we focused on achieving(More)
Office Hours: M&W 12:30-1:30 (and most other times when not in class) Materials: Cases/Readings (on-line & Target Copy Center) Class Notes (TBD in class) Business Articles (TBD electronically) Format: The assumption in this course is that you are relative novices with respect to marketing and that this may be the only marketing class you take. To achieve(More)
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