Learn More
This study examined the subnuclear distribution and transmitter content of neurons in the interpeduncular nucleus (IPN) that projected to the septum, dorsal hippocampal formation, and/or raphe. Following the injection of fast blue into the medial septum/diagonal band nucleus and rhodamine-conjugated microspheres into the dorsal hippocampal formation (or(More)
The distribution of anterogradely-labeled fibers and retrogradely-labeled cell bodies in the interpeduncular nucleus (IPN) was mapped after injections of wheat-germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) into various structures of the basal forebrain in adult rats. WGA-HRP injections into the medial septum/vertical limb of the diagonal(More)
In order to characterize further the origin of striatal afferents, adult rats underwent a unilateral intrastriatal infusion of 30% Evans Blue solution (0.2 - 0.5 mul). Labeled neurons were observed in ipsilateral substantia nigra, thalamus, cortex, ventromedial mesencephalic tegmentum and dorsal raphe. Several labeled neuronal somata, albeit considerably(More)
Recent findings suggest that exogenous gangliosides improve recovery of a learned behavior (alternation in a T-maze) which is thought to be related to sprouting after lesions of the entorhinal cortex. In the present investigation, we studied an unlearned behavior (the open-field hyperactivity resulting from bilateral entorhinal lesions) to evaluate whether(More)
The use of monoclonal antibodies to distinguish human sarcoma from carcinoma cells has been explored. Spleen cells from a BALB/c mouse immunized with a human malignant fibrohistiocytoma were fused with cells of the mouse P3U1 plasmacytoma cell line. Antibodies were then screened for reactivity against human sarcoma and carcinoma cells growing in culture.(More)
Cellular metabolic events accompanying postlesion synaptogenesis in the hippocampus were studied by analyzing incorporation of protein precursor ([3H]leucine) in the dentate gyrus. Adult rats were injected intravenously with [3H]leucine at periods from 2 to 60 days following unilateral destruction of the entorhinal cortex, and were killed 30 min later.(More)
Previous research has shown that exogenous gangliosides improve recovery of learned alternation after unilateral lesions of the entorhinal cortex. Since this recovery is thought to depend upon axonal sprouting, it has been hypothesized that ganglioside-induced improvement may be due to enhanced sprouting. The present study examined the effects of(More)
Four monoclonal antibodies (McAbs) previously generated against human soft tissue sarcomas and reacting with connective tissue differentiation antigens were evaluated for their interaction with tissues obtained from patients with classic Kaposi's sarcoma. Biopsy was performed on active neoplastic lesions from the skin of 26 patients, frozen sections were(More)