Bryan Carson

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CD4(+)CD25(+) regulatory T cells are crucial to the maintenance of tolerance in normal individuals. However, the factors regulating this cell population and its function are largely unknown. Estrogen has been shown to protect against the development of autoimmune disease, yet the mechanism is not known. We demonstrate that estrogen (17-beta-estradiol, E2)(More)
CD8+ T cell tolerance to self-proteins prevents autoimmunity but represents an obstacle to generating T cell responses to tumor-associated antigens. We have made a T cell receptor (TCR) transgenic mouse specific for a tumor antigen and crossed TCR-TG mice to transgenic mice expressing the tumor antigen in hepatocytes (gag-TG). TCRxgag mice showed no signs(More)
We describe a proposed universal design infrastructure that aims at promoting better opportunities for students with disabilities in STEM programs to understand multimedia teaching material. The Accessible Educational STEM Videos Project aims to transform learning and teaching for students with disabilities through integrating synchronized captioned(More)
Section 508 of the Rehabilitation Act [1] requires electronic and information technology communications to be in made available in an accessible format by alternative means perceptible by people with disabilities. These provisions apply to all entities-including colleges and universities-that receive Federal money (17 U.S.C. § 794). The Accessible(More)
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