Learn More
Previous studies have shown that lateral condensation of gutta-percha and sealer can provide an adequate apical seal. The purpose of this study was to compare the level of apical dye penetration when different sealers were used. One-hundred twenty-five teeth with single root canals were biomechanically prepared using the step-back technique and irrigation(More)
OBJECTIVE To describe the current Ebola virus epidemic and the potential options for treatment and prevention of Ebola virus disease. DATA SOURCES A PubMed literature search (1976 through October 20, 2014) was conducted using the search term Ebola. STUDY SELECTION AND DATA EXTRACTION Animal and human studies published in English were selected. Studies(More)
BACKGROUND Utilizing procalcitonin (PCT) levels to limit antimicrobial overuse would be beneficial from a humanistic and economic perspective. OBJECTIVE To assess whether introducing PCT at a teaching hospital reduced antimicrobial exposure in critically ill patients. METHODS Patients wereadmitted to the intensive care unit (ICU) for >72 hours with(More)
Biology is generating more data than ever. As a result, there is an ever increasing number of publicly available databases that analyse, integrate and summarize the available data, providing an invaluable resource for the biological community. As this trend continues, there is a pressing need to organize, catalogue and rate these resources, so that the(More)
  • Bryan M Bishop
  • 2014
PURPOSE The pharmacology, pharmacokinetics, clinical efficacy, safety, and role in therapy for riociguat are reviewed. SUMMARY Riociguat is the first member of a new class of medications, soluble guanylate cyclase stimulators. Riociguat is indicated for patients with resistant or recurrent chronic thromboembolic pulmonary hypertension (CTEPH) after(More)
Pulmonary arterial hypertension is a devastating disease. Before the 1990s, when pharmacologic treatment was finally approved, only supportive therapy was available, consisting of anticoagulation, digoxin, diuretics, and supplemental oxygen. Calcium channel blocker therapy was also an option, but only a small percentage of patients respond to it. However,(More)
A clinical review was made of 92 Isosit composite inlays that had been inserted in the mouth for a period ranging from seven months to four years four months. The direct clinical examination, the indirect model and colour slide examination showed that only one inlay did not satisfy the USPHS (modified) criteria for a functioning restorative system.