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Normal values are given for the activities of pyruvate carboxylase (E.C., mitochondrial phosphoenolpyruvate carboxykinase (E.C., PEPCK), and citrate synthase (E.C. in fibroblasts, lymphocytes, and leukocytes. Also given are values for these enzymes in the leukocytes and fibroblasts from a severely mentally and developmentally(More)
Exogenous adenosine diphosphate (ADP), the most potent mitogen for nontransformed African green monkey kidney epithelial cells of the BSC-1 line, rapidly alters the appearance of the cell monolayer. Examination of the cells with indirect immunofluorescence using monoclonal antibodies reveals a considerable reorganization of cytokeratin filaments without a(More)
Pyruvate carboxylase (E.C. activity was determined in the circulating peripheral lymphocytes and cultured skin fibroblasts from the family of a patient with hepatic, cerebral, renal cortical, leukocyte, and fibroblast pyruvate carboxylase deficiency (PC Portland deficiency). Lymphocyte activities were: mother, 33--39%; father, 11--29%; brother,(More)
Epidermal growth factor (EGF) has previously been found in cells of the thick ascending limb of Henle's loop (TALH) and the first part of the distal convoluted tubule (DCT) of mouse kidney. To define the cellular localization of the mRNA that encodes the protein precursor of EGF, we used high-resolution in situ hybridization. EGF precursor cDNA was(More)
  • B Atkin, R Leiringer, Joon-Hong Paek
  • 2005
SUMMARY: Analysing customers' likely acceptance of new technology before it is marketed is a common practice. Yet, in the case of digital home services, there is scant evidence of this being a routine practice. This paper reports on a study whose twofold purpose is to analyse customers' acceptance of digital home services and to establish the direction of(More)
A child with lactic acidosis, severe mental and developmental retardation, and proximal renal tubular acidosis is presented. Biopsy and autopsy studies show severe hepatic, renal cortical, and cerebral deficiencies in pyruvate carboxylase (EC activity. The patient had 1.81 +/- 0.20 units/g fresh weight at biopsy and 0.75 +/- 0.07 units/g fresh(More)
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