Bryan A. Daniels

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Generation of center-surround antagonistic receptive fields in the outer retina occurs via inhibitory feedback modulation of presynaptic voltage-gated calcium channels in cone photoreceptor synaptic terminals. Both conventional and unconventional neurotransmitters, as well as an ephaptic effect, have been proposed, but the intercellular messaging that(More)
As in many CNS neurons, retinal ganglion cells (RGCs) receive fast synaptic activation through postsynaptic ionotropic receptors. However, the potential role of postsynaptic group I metabotropic glutamate receptors (mGluRs) in these neurons is unknown. In this study we first demonstrated that the selective group I mGluR agonist(More)
NMDA receptor (NMDAR) activation is enhanced by d-serine or glycine acting at a specific binding site. Previous work has shown d-serine enhancement of NMDAR currents in retinal ganglion cells. One of the major functions of most NMDA channels is to permit calcium influx into cells. We show that d-serine enhances glutamate-induced calcium responses in(More)
D-Serine is an important signaling molecule throughout the central nervous system, acting as an N-methyl-D-aspartate (NMDA) receptor coagonist. This study investigated the D-serine modulation of non-NMDA ionotropic glutamate receptors expressed by inner retinal neurons. We first identified that the degradation of endogenous retinal D-serine, by application(More)
Horizontal cells of the vertebrate retina have large receptive fields as a result of extensive gap junction coupling. Increased ambient illumination reduces horizontal cell receptive field size. Using the isolated goldfish retina, we have assessed the contribution of nitric oxide to the light-dependent reduction of horizontal cell receptive field size.(More)
2 3 Slow excitation of cultured rat retinal ganglion cells by activating group I metabotropic 4 glutamate receptors 5 6 Jianing Yu, Bryan A. Daniels and William H. Baldridge 7 Laboratory for Retina and Optic Nerve Research, Departments of Anatomy & Neurobiology and 8 Ophthalmology & Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada, B3H(More)
Corrigia obscura sp. n. was found in the pancreatic ducts of a black duck, Anas rubripes. This is the first record of the genus Corrigia from an anseriform bird and from North America. Corrigia obscura differs from other Corrigia spp. by having a greater relative forebody length and greater relative body width. Noticeable hyperplasia and sloughing of the(More)
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