Bruno de Abreu Silva

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BACKGROUND The pathophysiology of HFE-derived Hereditary Hemochromatosis and the function of HFE protein in iron homeostasis remain uncertain. Also, the role of alternative splicing in HFE gene expression regulation and the possible function of the corresponding protein isoforms are still unknown. The aim of this study was to gain insights into the(More)
Nonsense-mediated decay (NMD) is an mRNA surveillance pathway that selectively recognizes and degrades defective mRNAs carrying premature translation-termination codons. However, several studies have shown that NMD also targets physiological transcripts that encode full-length proteins, modulating their expression. Indeed, some features of physiological(More)
Tool Flow Proposal In this research, we present a work in progress tool to exploit power/performance optimization techniques in FPGA-based asymmetric multi-core systems. The tool flow, which is proposed in Figure 1, is divided in two phases: compilation and execution time. In the first phase, the application code is given as input to the ROSE-based(More)
In this paper, the acceleration of algorithms using a design of a field pro-grammable gate array (FPGA) as a prototype of a static dataflow architecture is discussed. The static dataflow architecture using operators interconnected by parallel buses was implemented. Accelerating algorithms using a dataflow graph in a reconfigurable system shows the potential(More)
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