Bruno de Abreu Silva

Learn More
Tumor necrosis factor (TNF)-alpha has been reported to modulate brain injury, but remarkably, little is known about its effects on neurogenesis. We report that TNF-alpha strongly influences survival, proliferation, and neuronal differentiation in cultured subventricular zone (SVZ) neural stem/progenitor cells derived from the neonatal P1-3 C57BL/6 mice. By(More)
Stem cells of the subventricular zone (SVZ) represent a reliable source of neurons for cell replacement. Neuropeptide Y (NPY) promotes neurogenesis in the hippocampal subgranular layer and the olfactory epithelium and may be useful for the stimulation of SVZ dynamic in brain repair purposes. We describe that NPY promotes SVZ neurogenesis. NPY (1 microM)(More)
Heterogeneous Multi-core Processor (HMP) is a set of cores exposing the same instruction set architecture (ISA). The cores in HMPs can differ relative to performance, area, power, and micro-architecture design. Many researchers have investigated HMPs as an alternative to optimize the relationship between power consumption and performance. Usually, the(More)
In the present study we investigated the effects of phenolic compounds present in Hypericum perforatum against neuronal excitotoxicity and mitochondrial dysfunction. Quercetin, kaempferol and biapigenin significantly reduced neuronal death caused by 100 microM kainate plus 100 microM N-methyl-D-aspartate. The observed neuroprotection was correlated with(More)
In the present study we assessed the neuroprotective role of a Hypericum perforatum ethanolic extract and obtained fractions in amyloid-beta peptide (Abeta)((25-35))-induced cell death in rat cultured hippocampal neurons. Lipid peroxidation was used as a marker of oxidative stress by following the formation of TBARS in rat cortical synaptosomes, after(More)
Subventricular zone (SVZ) cell cultures contain mixed populations of immature cells, neurons, astrocytes, and progenitors in different stages of development. In the present work, we examined whether cell types of the SVZ could be functionally discriminated on the basis of intracellular free calcium level ([Ca(2+)](i)) variations following KCl and histamine(More)
In embedded systems, energy efficiency is the new fundamental performance limiter. Considering that, many techniques were applied at different development levels, such as co-design, compilers, schedulers, run-time management, and applications. The fusion of techniques from different levels has also been exploited to increase the optimization opportunities.(More)
In this study, we investigated the effects of biapigenin, a biflavone present in the extracts of Hypericum perforatum, in rat brain mitochondrial bioenergetics and calcium homeostasis. We found that biapigenin significantly decreased adenosine diphosphate (ADP)-induced membrane depolarization and increased repolarization (by 68 and 37%, respectively). These(More)
Combining dataflow concepts with reconfigurable computing provides a great potential to exploit the application parallelism efficiently. However, to express such parallelism cannot be a trivial task. Therefore, there is a great effort to automatically translate programs originally written in procedural languages (like C and Java) into dataflow architectures(More)