Bruno O. Shubert

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The patch-clamp method was used to study the effect of N-propyl ajmaline (NPA) on sodium currents (INa) in enzymatically isolated cells of adult rats. When applied at concentrations of 10(-5)--2 X 10(-5) M NPA produced a use-dependent inhibition of INa. The rate and depth of this blockade increased with NPA concentration, frequency and magnitude of(More)
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