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Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems
Selenocysteine (Sec) is the 21st amino acid in the genetic code, inserted in response to UGA codons with the help of RNA structures, the SEC Insertion Sequence (SECIS) elements. The three domains ofExpand
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Regulated methionine oxidation by monooxygenases.
Protein function can be regulated via post-translational modifications by numerous enzymatic and non-enzymatic mechanisms, including oxidation of cysteine and methionine residues. Redox-dependentExpand
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Iron Metabolism in Pathogenic Trypanosomes
Trypanosomatids comprise a large group of flagellated unicellular protists with free-living and parasitic lifestyles. Several members of this family are widely known for being vertebrate pathogens ofExpand
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1H, 13C and 15N resonance assignment of the mature form of monothiol glutaredoxin 1 from the pathogen Trypanosoma brucei
Glutaredoxins (Grx) are small proteins, conserved throughout all the kingdoms of life, which are engaged in a wide variety of biological processes. According to the number of cysteines in theirExpand
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1H, 13C and 15N resonance assignment of the cytosolic dithiol glutaredoxin 1 from the pathogen Trypanosoma brucei
Trypanosomatids are parasites responsible for several tropical and subtropical diseases, such as Chaga’s disease, sleeping sickness and Leishmaniasis. In contrast to the mammalian host, theExpand
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Stress Response in the Infective Stage of Trypanosoma brucei
African trypanosomes (Trypanosoma brucei sp.) are unicellular eukaryotic organisms that undergo a complex life cycle shuttling between an invertebrate (vector) and a mammalian host. The parasitesExpand
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An NMR-based biosensor to measure stereo-specific methionine sulfoxide reductase (MSR) activities in vitro and in vivo.
Oxidation of protein methionines to methionine-sulfoxides (MetOx) is associated with several age-related diseases. In healthy cells, MetOx is reduced to methionine by two families of conservedExpand
An NMR-based biosensor to measure stereo-specific methionine sulfoxide reductase (MSR) activities in vitro and in vivo
Oxidation of protein methionines to methionine-sulfoxides (MetOx) is associated with several age-related diseases. In healthy cells, MetOx is reduced to methionine by two families of conservedExpand
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.
Oxidant stress can contribute to health and disease. Here we show that invertebrates and vertebrates share a common stereospecific redox pathway that protects against pathological responses toExpand