Stacia L Kargman1
Makoto M Taketo1
Margaret Landis1
Larry A. Gatlin1
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Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H2: constitutive COX-1 and inducible COX-2. To assess the role of COX-2 in colorectal tumorigenisis, we determined the effects of COX-2 gene (Ptgs2) knockouts and a novel COX-2 inhibitor on Apc delta716 knockout mice, a model of human familial adenomatous polyposis. A Ptgs2(More)
The objectives of this study were to measure the apparent surface acidity of common excipients and to correlate the acidity with the chemical stability of an acid-sensitive active pharmaceutical ingredient (API) in binary API-excipient powder mixtures. The acidity of 26 solid excipients was determined by two methods, (i) by measuring the pH of their(More)
We have modified Daresbury Laboratory's replicated data strategy (RDS) parallel molecular dynamics (MD) package DL_POLY (version 2.13) to study the granular dynamics of frictional elastic particles. is a MD package originally developed to study liquid state and macromolecular systems by accounting for various molecular interaction forces. The particles of(More)
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