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BACKGROUND A number of US observational studies reported an increased mortality risk with higher intact parathyroid hormone (iPTH), calcium and/or phosphate. The existence of such a link in a European haemodialysis population was explored as part of the Analysing Data, Recognising Excellence and Optimising Outcomes (ARO) Chronic Kidney Disease (CKD)(More)
Transforming growth factor (TGF)-beta1 is a growth factor involved in the mechanisms of lung repair and fibrosis that follow inflammatory processes. We sought to examine the link between the generation of reactive oxygen intermediates (ROI) or reactive nitrogen intermediates (RNI) by inflammatory cells and the expression of TGF-beta1 by alveolar epithelial(More)
Increasing evidence supports a role of cytokines, tumor necrosis factor alpha (TNFa), interleukin-1 (IL-1), and lL-6 in the development of endotoxin-induced acute renal failure. Several activities of these cytokines require a local rather than a systemic production and function. Thus, this study investigates the chronology of cytokine expression in(More)
Leptin, the product of the ob gene, regulates food intake, energy balance and lymphocyte functions. Receptor mutated animals have reduced production of proinflammatory cytokines. To analyze the direct effects of leptin (0.1 nM(/1 mM) on cytokine production from colonic cells, we examined pro-inflammatory (IL-8, MCP-1, IL-6 and TNF-alpha) and(More)
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