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In the postnatal and adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the main source of neural stem cells (NSCs) that generate olfactory neurons and oligodendrocytes (OLs), the myelinating cells of the CNS. Here, we provide evidence of a primary role for canonical Wnt/β-catenin signaling in regulating NSC fate along(More)
Neurogenesis does not stop abruptly at birth, but persists in specific brain regions throughout life. The neural stem cells (NSCs) located in the largest germinal region of the forebrain, the ventricular-subventricular zone (V-SVZ), replenish olfactory neurons throughout life. However, V-SVZ NSCs are heterogeneous: they have different embryonic origins and(More)
Neural stem cell (NSC) differentiation is a complex multistep process that persists in specific regions of the postnatal forebrain and requires tight regulation throughout life. The transcriptional control of NSC proliferation and specification involves Class II (proneural) and Class V (Id1-4) basic helix-loop-helix (bHLH) proteins. In this study, we(More)
Throughout postnatal life in mammals, neural stem cells (NSCs) are located in the subventricular zone (SVZ) of the lateral ventricles. The greatest diversity of neuronal and glial lineages they generate occurs during early postnatal life in a region-specific manner. In order to probe heterogeneity of the postnatal SVZ, we microdissected its dorsal and(More)
  • Christoph David Perels, Felix Bürgin, Stefan Eberli, Jürg Fröhlich, Pier-Andrea Francese, Chiara Martelli +6 others
  • 2008
for the co-examination of my thesis as well as for the fruitful projects and inputs that led to this thesis. At the IIS, I would like to thank Andreas Burg for his patience and support over many years and several projects. I am grateful to Nor-bert Felber for giving me the opportunity to start in the interesting field of VLSI for communications. Many thanks(More)
  • Timm Höhr, Hartung-Gorre Verlag Konstanz, Wolfgang Fichtner, Qiuting Huang, Heinz Jäckel, Hans Melchior +13 others
  • 2006
Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at Acknowledgments First of all, I would like to thank Prof. Wolfgang Fichtner for the opportunity to work and learn at the Institut für Integrierte Systeme where I found excellent working conditions as well as(More)
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