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The β-haemoglobinopathies are the most prevalent inherited disorders worldwide. Gene therapy of β-thalassaemia is particularly challenging given the requirement for massive haemoglobin production in a lineage-specific manner and the lack of selective advantage for corrected haematopoietic stem cells. Compound β(E)/β(0)-thalassaemia is the most common form(More)
The effects of acute anxiety on food intake and preferences were investigated in 12 men awaiting surgery for hernia. Their lunch intake was measured on the day prior to surgery and again after recovery, one month later. Their anxiety was rated on both test days as well as the palatability of the foods they selected and ingested ad libitum. Anxiety was(More)
High doses of recombinant human erythropoietin (rhEpo) are required for the treatment of chronic anemia. Thus, it is clear that therapy for chronic anemia would greatly benefit from an erythropoietin derivative with increased erythropoietic activity rather than the native endogenous hormone. In this report, the activity of a human Epo-Epo dimer protein,(More)
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