Bruno Costa-Silva

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The neural crest (NC) is a model system used to investigate multipotency during vertebrate development. Environmental factors control NC cell fate decisions. Despite the well-known influence of extracellular matrix molecules in NC cell migration, the issue of whether they also influence NC cell differentiation has not been addressed at the single cell(More)
Astrocytes clearly play a role in neuronal development. An indirect mechanism of thyroid hormone (T3) in the regulation of neuronal development mediated by astrocytes has been proposed. T3 alters the production and organization of the extracellular matrix (ECM) proteins and proteoglycans, producing a high-quality substrate for neuronal differentiation. The(More)
Thyroid hormone (T3) plays an essential role in the central nervous system development. Astrocytes mediate many of the T3 effects in the growth and differentiation of cerebellum. In culture, T3 induces cerebellar astrocytes to secrete growth factors, mainly FGF2, and alters the expression and organization of the extracellular matrix (ECM) proteins, laminin,(More)
Folate deficiency and hyperhomocysteinemia have long been associated with developmental anomalies, particularly neural tube defects and neurocristopathies—a group of diverse disorders that result from defective growth, differentiation, and migration of neural crest (NC) cells. However, the exact mechanisms by which homocysteine (Hcys) and/or folate(More)
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