Bruno Brandão Fischer

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In the postnatal and adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the main source of neural stem cells (NSCs) that generate olfactory neurons and oligodendrocytes (OLs), the myelinating cells of the CNS. Here, we provide evidence of a primary role for canonical Wnt/β-catenin signaling in regulating NSC fate along(More)
Neurogenesis does not stop abruptly at birth, but persists in specific brain regions throughout life. The neural stem cells (NSCs) located in the largest germinal region of the forebrain, the ventricular-subventricular zone (V-SVZ), replenish olfactory neurons throughout life. However, V-SVZ NSCs are heterogeneous: they have different embryonic origins and(More)
Neural stem cell (NSC) differentiation is a complex multistep process that persists in specific regions of the postnatal forebrain and requires tight regulation throughout life. The transcriptional control of NSC proliferation and specification involves Class II (proneural) and Class V (Id1-4) basic helix-loop-helix (bHLH) proteins. In this study, we(More)
Throughout postnatal life in mammals, neural stem cells (NSCs) are located in the subventricular zone (SVZ) of the lateral ventricles. The greatest diversity of neuronal and glial lineages they generate occurs during early postnatal life in a region-specific manner. In order to probe heterogeneity of the postnatal SVZ, we microdissected its dorsal and(More)
Innovation is increasingly becoming an internationalized process and a strategy that has recently been playing a central role in this scenario is that of R&D collaboration. To assess the outcomes of this strategy we develop an evaluation of Eureka Programme's impact for the case of Spanish companies participating in this initiative and that had projects(More)
Technological innovation policies represent a strategic area in the field of public policy, and they are bound to face a continuous process of evaluation in order to analyze their effective contribution, as well as to allow their adaptation to changing economic and social contexts. However, a well-known weakness that many policy and scientific evaluations(More)
cipantes es propuesta en 3 conglomerados: (1) Risky Innovators; (2) Inventors; y (3) Consistent Innovators. Abstract Innovation is a process that faces several " market failure " situations and for this reason – and for being considered one of the main drivers of economic growth throughout the world – a large number of governmental and supranational(More)
Foreign direct investment (FDI) is assumed to be a source of knowledge flows across National Innovation Systems, with particular relevance for developing countries. Nonetheless, empirical assessments are usually manufacturing-oriented, providing only a partial view of the phenomena under scrutiny. This article aims at contributing to this body of literature(More)
Increasing attention has been paid to the creation of spatially concentrated environments (industrial agglomerations or clusters) that aim at fostering firm-level competitiveness. However, while much has been said about clusters in general, less attention has been paid to structural governance within these agglomerations. This paper discusses the economic(More)
The Southern Common Market (mercosur), widely recognized as one of the most advanced regional integration schemes worldwide, is increasingly attractive to multinational enterprises and also very active in outward investments, despite persistent innovation and competitiveness gaps. In this paper we analyse internationalization and technology trends in(More)