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Higher risk of aggressive pancreatic neuroendocrine tumors in MEN1 patients with MEN1 mutations affecting the CHES1 interacting MENIN domain.
CONTEXT Sixty to 80% of multiple endocrine neoplasia type 1 (MEN1) patients develop pancreatic neuroendocrine neoplasias (pNENs), which reveal an aggressive behavior in 10%-20% of patients. CausativeExpand
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Prevalence of BRCA2 and CDKN2a mutations in German familial pancreatic cancer families
Previous small scale studies reported that deleterious BRCA2 and CDKN2a germline mutations contribute to a subset of families with inherited pancreatic cancer. As the prevalence of those mutations inExpand
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Frequent methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene in pancreatic endocrine tumors.
Molecular mechanisms contributing to the tumorigenesis of pancreatic endocrine tumors (PETs) are still not well understood. Allelic deletions at chromosome 22q12.3 were detected in about 30-60% ofExpand
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Chromosome 22q in pancreatic endocrine tumors: identification of a homozygous deletion and potential prognostic associations of allelic deletions.
OBJECTIVE A variety of human tumors frequently show allelic deletions of chromosome 22q, suggesting that inactivation of one or more tumor suppressor genes in this region is important for theirExpand
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Alterations of the Tissue Inhibitor of Metalloproteinase-3 (TIMP3) Gene in Pancreatic Adenocarcinomas
Objectives: Tissue inhibitor of metalloproteinase-3 (TIMP3) antagonizes matrix metalloproteinase activity and can suppress tumor growth, angiogenesis, invasion, and metastases. In the present study,Expand
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LCN2 and TIMP1 as Potential Serum Markers for the Early Detection of Familial Pancreatic Cancer.
High-risk individuals of familial pancreatic cancer (FPC) families are considered to be good candidates for screening programs to detect early PC or its high-grade precursor lesions, especiallyExpand
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RNASEL germline variants are associated with pancreatic cancer
The RNASEL (encoding ribonuclease L) gene Glu265X mutation has been implicated in familial prostate cancer, and an association between the RNASEL Arg462Gln variant and sporadic and familial prostateExpand
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Expression and function of VLA‐α2, ‐α3, ‐α5 and ‐α6‐integrin receptors in pancreatic carcinoma
The expression of the VLA‐integrins α2, α3, v5 and α6 was studied immunohistochemically in tissue samples from ductal pancreatic cancer, chronic pancreatitis, normal pancreas and in 8 cell lines ofExpand
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Clinical impact of TP53 alterations in adrenocortical carcinomas
BackgroundTo evaluate the role of somatic TP53 mutations and to correlate somatic and germline mutations with results of immunostaining, a large cohort of ACC patients was analyzed.Patients andExpand
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A novel insulinoma tumor suppressor gene locus on chromosome 22q with potential prognostic implications.
The molecular mechanisms contributing to the tumorigenesis of insulinomas are still poorly understood. As moderate to high rates of LOH have been found on chromosome 22q in gastrinomas, we performedExpand
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