Bruna M Couri

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Pelvic organ prolapse is a vaginal protrusion of female pelvic organs. It has high prevalence worldwide and represents a great burden to the economy. The pathophysiology of pelvic organ prolapse is multifactorial and includes genetic predisposition, aberrant connective tissue, obesity, advancing age, vaginal delivery and other risk factors. Owing to the(More)
A significant number of women experience stress urinary incontinence (SUI), which greatly affects their quality of life. Recent research investigating utilization of stem cells and their derivatives for the prevention and treatment of SUI has been performed to test the effect of cell source and method of administration in several animal models of SUI. The(More)
OBJECTIVES Lysyl oxidase-like 1 knockout (Loxl1) mice demonstrate deficient elastin homeostasis associated with pelvic organ prolapse (POP). To further investigate the pathophysiology of POP in these animals, a genetically matched homozygous positive (Loxl1) or wild-type strain is needed. This study sought to create and validate genetically matched Loxl1(More)
Marianne Koch,* Rufus Cartwright, Kari A.O. Tikkinen, Nazema Y. Siddiqui, Bruna M. Couri, William Gibson, Paula Igualada-Martinez, and Christopher R. Chapple Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria Department of Epidemiology & Biostatistics, Imperial College London, London, United Kingdom Department of(More)
AIMS Urodynamics (UDS) is widely used for the diagnosis of lower urinary tract dysfunction. Air-Charged catheters (ACC), one of the newer technologies for UDS pressure recording, has been adopted in growing numbers around the world for the past 15 years. Currently, there is a lack of published studies characterizing specific performance of the ACC. Since(More)
BACKGROUND Functional status plays an important role in the comprehensive characterization of older adults. Functional limitations are associated with an increased risk of adverse treatment outcomes, but there are limited data on the prevalence of functional limitations in older women with pelvic floor disorders. OBJECTIVE The aim of the study was to(More)
OBJECTIVE To test the tensile properties of knotted suture made of 4 different suture materials and exposed to petroleum gauze. STUDY DESIGN We tested the tensile strength of United States Pharmacopeia size 0-0 gauge polydioxanone, polyglyconate, glycolide/lactide copolymer, and silk when exposed to petroleum packing or saline. Suture materials were(More)
OBJECTIVES The aim of this study was to determine the effect of pregnancy and delivery mode on cytokine expression in the pelvic organs and serum of lysyl oxidase like-1 knockout (LOXL1 KO) mice, which develop pelvic organ prolapse after delivery. METHODS Bladder, urethra, vagina, rectum, and blood were harvested from female LOXL1 KO mice during(More)
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