Bruce van Brunt

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The growth of human cancers is characterised by long and variable cell cycle times that are controlled by stochastic events prior to DNA replication and cell division. Treatment with radiotherapy or chemotherapy induces a complex chain of events involving reversible cell cycle arrest and cell death. In this paper we have developed a mathematical model that(More)
Most anti-cancer drugs in use today exert their effects by inducing a programmed cell death mechanism. This process, termed apoptosis, is accompanied by degradation of the DNA and produces cells with a range of DNA contents. We have previously developed a phase transition mathematical model to describe the mammalian cell division cycle in terms of cell(More)
Conservation laws for partial differential equations can be characterised by an operator, the characteristic and a condition involving the adjoint of the Fréchet derivatives of this operator and the operator defining the partial differential equation. This approach was developed by Anco and Bluman and we exploit it to derive conditions for second-order(More)
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