Bruce Winter

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Without the MCNC and ISPD98 benchmarks, it would arguably not have been possible for the academic community to make consistent advances in physical design over the last decade. While still being used extensively in placement and floorplanning research, those benchmarks can no longer be considered representative of today's (and tomorrow's) physical design(More)
Mycophenolic acid (MPA) is a selective inhibitor of inosine 5'-monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme of de novo synthesis of guanine nucleotides. The isoenzyme IMPDH2 predominates in activated lymphocytes, and its inhibition by MPA is part of standard immunosuppressive regimens. Yet, there are significant unexplained differences in(More)
The Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) measures extracellular neurotransmitter concentration in vivo and displays the data graphically in nearly real time. WINCS implements two electroanalytical methods, fast-scan cyclic voltammetry (FSCV) and fixed-potential amperometry (FPA), to measure neurotransmitter(More)
INTRODUCTION The heart rate dependence of QT interval duration is abnormal in patients with congenital long QT syndrome. Patients with LQT1 have a defective I(Ks) current, a major determinant of QT response to heart rate. METHODS AND RESULTS We studied the heart rate dependence of QT interval duration in different long QT syndrome genotypes and control(More)
BACKGROUND Increased QT variability (QTV) has been reported in conditions associated with ventricular arrhythmias. Data on QTV in patients with congenital long QT syndrome (LQTS) are limited. METHODS Ambulatory electrocardiogram recordings were analyzed in 23 genotyped LQTS patients and in 16 healthy subjects (C). Short-term QTV was compared between C and(More)
PPARgamma is a transcription factor of nuclear receptor superfamily, involved in the regulation of inflammation. We investigated the influence of PPARgamma-ligands, 15-deoxy-delta12,14 prostaglandin-J2 (15d-PGJ2), and ciglitazone, on the generation of interleukin-8 (IL-8) by the human microvascular endothelial cell line (HMEC- 1). Expression of PPARgamma in(More)
This report summarises and builds on the results of the “Directions and Methodologies for Empirical Software Engineering Research” group discussion. In particular, we considered the strengths, weaknesses, opportunities and threats to empirical software engineering research in light of the discussions and presentations during the workshop. The following(More)
Organ cultures of arteries have been used to study growth responses, proliferation, and contractility. However, the function of specific-ion channels in cultured arteries has not been investigated. ATP-sensitive K+ (KATP) channels play an important role in the control of arterial tone. The goal of this study was to determine the functional state of KATP(More)
In connection with a workshop titled ’A Collective Demonstration of Program Comprehension Tools’ held during the CASCON conference in 1999, an experiment was conducted on how well expert users of program comprehension tools were able to perform specific program understanding and maintenance tasks on the xfig drawing program using these tools. This paper(More)
Cigarette smoking is one of the most important and preventable risk factors for atherosclerosis. However, because of the complex composition of cigarette smoke, the detailed pathophysiological mechanisms are not fully understood. Based on controversial reports on the pro-atherogenic activity of cigarette smoke condensate, also called tar fraction (CSC), we(More)