Bruce T Lamb

Sort by:

Increased App Expression in a Mouse Model of Down's Syndrome Disrupts NGF Transport and Causes Cholinergic Neuron Degeneration

Ahmad Salehi, Jean-Dominique M Delcroix, +17 authors William C Mobley
Neuron
2006

Degeneration of basal forebrain cholinergic neurons (BFCNs) contributes to cognitive dysfunction in Alzheimer's disease (AD) and Down's syndrome (DS). We used Ts65Dn and Ts1Cje mouse models of DS to… (More)

The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours

Kirsten K. Youngren, Douglas Coveney, +10 authors Angabin Matin
Nature
2005

In mice, the Ter mutation causes primordial germ cell (PGC) loss in all genetic backgrounds. Ter is also a potent modifier of spontaneous testicular germ cell tumour (TGCT) susceptibility in the 129… (More)

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain.

Kaushik Ghosal, Daniel L. Vogt, Man Liang, Yong Shen, Bruce T Lamb, Sanjay W Pimplikar
Proceedings of the National Academy of Sciences…
2009

The hypothesis that amyloid-beta (Abeta) peptides are the primary cause of Alzheimer's disease (AD) remains the best supported theory of AD pathogenesis. Yet, many observations are inconsistent with… (More)

CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.

Sungho Lee, Nicholas H. Varvel, +4 authors Bruce T Lamb
The American journal of pathology
2010

Microglia, the primary immune effector cells in the brain, continually monitor the tissue parenchyma for pathological alterations and become activated in Alzheimer's disease. Loss of signaling… (More)

Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected].

Bruce T Lamb, Sangram S. Sisodia, +6 authors John D. Gearhart
Nature genetics
1993

Overexpression of the gene encoding the beta-amyloid precursor protein (APP) may have a key role in the pathogenesis of both Alzheimer's disease (AD) and Down Syndrome (DS). We have therefore… (More)

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

Taylor R. Jay, Crystal M Miller, +17 authors Bruce T Lamb
The Journal of experimental medicine
2015

Variants in triggering receptor expressed on myeloid cells 2 (TREM2) confer high risk for Alzheimer's disease (AD) and other neurodegenerative diseases. However, the cell types and mechanisms… (More)

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

Kiran Bhaskar, Megan E Konerth, Olga Nicole Kokiko-Cochran, Astrid E Cardona, Richard M Ransohoff, Bruce T Lamb
Neuron
2010

Aggregates of the hyperphosphorylated microtubule-associated protein tau (MAPT) are an invariant neuropathological feature of tauopathies. Here, we show that microglial neuroinflammation promotes… (More)

Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease.

Wai Haung Yu, Asok Kumar, +5 authors Ralph A. Nixon
The international journal of biochemistry & cell…
2004

In Alzheimer's disease (AD), the neuropathologic hallmarks of beta-amyloid deposition and neurofibrillary degeneration are associated with early and progressive pathology of the endosomal-lysosomal… (More)

Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease.

Nicholas H. Varvel, Kiran Bhaskar, Anita Ramdas Patil, Sanjay W Pimplikar, Karl Herrup, Bruce T Lamb
The Journal of neuroscience : the official…
2008

Neurons subject to degeneration in Alzheimer's disease (AD) exhibit evidence of re-entry into a mitotic cell cycle even before the development of substantial AD brain pathology. In efforts to… (More)

Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice.

Gjumrakch Aliev, Dilara Seyidova, +9 authors Carl Cotman
Annals of the New York Academy of Sciences
2002

We have studied the ultrastructural features of vascular lesions and mitochondria in brain vascular wall cells from human AD brain biopsy, human short postmortem brain tissues, and yeast artificial… (More)

Filter Results:

Publication Year

Publication Type

Co-author

Journals and Conferences