Bruce Stafford

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There are few epidemiologic data available to address the question of potential carcinogenic effects of hydrogen chloride (HCl) exposure on humans. An opportunity arose to augment a nominal HCl exposure classification that had been done earlier for a nested case-control study of lung cancer among a cohort of chemical manufacturing employees. Working from(More)
Twenty-one patients with nonresectable refractory meningiomas were registered on a study giving tamoxifen 40 mg per M2 b.i.d. for four days, then 10 mg b.i.d. thereafter. Nineteen were eligible and evaluated for response. One patient (5%) achieved an MRI-documented partial response while two had a minor response measured on CT scan which was of short(More)
To estimate prevalence of back pain and joint problems in employees of a chemical manufacturing company, a questionnaire was administered during medical surveillance examinations between 1987 and 1989. Among 5903 employees completing the questionnaire 35.4% reported back or joint pain during the past year. Back pain lasting 30 days or more occurred in 5.3%(More)
Mortality in a cohort of 770 workers with potential pentachlorophenol (PCP) exposure was evaluated from 1940 through 1989. The study cohort is a subset of a larger cohort of workers with potential exposure to higher chlorinated dioxins. Total mortality and cancer mortality in the PCP cohort were slightly lower than expected in comparison to the U.S. white(More)
The disposition of morphine in rat brain and serum was determined over 48 hr after subcutaneous doses. Free morphine was measured by a specific assay using 3H-labeling together with high-pressure liquid chromatography separation, with a sensitivity of 1 nM (0.3 ng of morphine per ml). This study revealed the persistence of free morphine in nanomolar(More)
BACKGROUND Social and economic development together with demographic changes and health interventions have resulted in an increase in life expectancy and a rapidly ageing population in Mexico. Whether people will live longer active and independent lives is still, however, unknown. We will address this question, providing the first estimates of active life(More)
UNLABELLED We studied the ranking of osteoporosis (OP) medication attributes in a convenience sample of four different racial/ethnic groups in the United States. Our study showed that postmenopausal women differ in the ranking of OP medication attributes based on age, educational level, income, and prior fracture history. INTRODUCTION Decision making(More)
DBCP (1,2-dibromo-3-chloropropane), a nematocide, was used in the United States from the mid-1950s until 1977. The U.S. Environmental Protection Agency (EPA) restricted and eventually banned its use after the 1977 discovery of DBCP-induced sterility in production workers. The present study is an update of the mortality (1957-1989) experience of a cohort of(More)
A major objective of the epidemiology department of the Dow Chemical Company is to report at periodic intervals the cause-specific mortality experience of its employees. This study analyzed the cause-specific mortality experience of 4,229 male and female employees of the Louisiana Division who were employed for at least 1 year from 1956 through 1986.(More)
Nonparticipants in general population health surveys have been found to be less healthy than participants, but data on nonparticipants in work-site health surveys have been more scarce. We compared cause-specific mortality among 11,156 male employees of The Dow Chemical Company who participated in at least one work-site health examination between 1967 and(More)