Bruce Pomeranz

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OBJECTIVE To estimate the incidence of serious and fatal adverse drug reactions (ADR) in hospital patients. DATA SOURCES Four electronic databases were searched from 1966 to 1996. STUDY SELECTION Of 153, we selected 39 prospective studies from US hospitals. DATA EXTRACTION Data extracted independently by 2 investigators were analyzed by a(More)
Spectral analysis of spontaneous heart rate fluctuations were assessed by use of autonomic blocking agents and changes in posture. Low-frequency fluctuations (below 0.12 Hz) in the supine position are mediated entirely by the parasympathetic nervous system. On standing, the low-frequency fluctuations increase and are jointly mediated by the sympathetic and(More)
When human polymorphonuclear basophils, a type of white blood cell with antibodies of the immunoglobulin E (IgE) type on its surface, are exposed to anti-IgE antibodies, they release histamine from their intracellular granules and change their staining properties. The latter can be demonstrated at dilutions of anti-IgE that range from 1 x 10(2) to 1 x(More)
Saphenous nerve sprouting was measured behaviorally and histologically after chronic sciatic denervation in the adult rat. The effect of electrical stimulation (either weak DC fields, or stronger AC fields) on the rate of sprouting of the intact saphenous was studied. Sprouting was enhanced by DC fields (1 microA) if the cathode was placed distal to the(More)
The left sciatic nerve was cut and ligated in adult rats (chronic denervation). Twenty-one days later the right sciatic nerve was cut and ligated (acute denervation). The somatotopic maps of the surviving intact saphenous nerves (left and right) were compared on day 21 by recording from single interneurons in the dorsal horn of the spinal cord. On the acute(More)
1. In normal kittens and cats, cells in a region of primary somatosensory cortex (SI) responded exclusively to input from the contralateral front paw; we called this area paw cortex (PC). A neighboring region of SI responded to input from the contralateral forearm above the wrist; we called this area forearm cortex (FC). The centers of PC and FC were about(More)
When a weak direct current (DC) of 10 microA driven by an implantable device was applied to a crushed sciatic nerve in 9-10-month-old rats, regeneration was accelerated as assessed electrophysiologically. Rats underwent a sciatic nerve crush of the right leg and were randomly assigned to one of three groups: (i) Cathode Distal (CD); (ii) Sham Implant (SI);(More)
Direct current (DC) electrical stimulation of the hindpaw is shown to enhance sciatic motor nerve regeneration in the adult rat. Cathodal stimulation, using weak currents (10 microA/cm2; field strength approximately 100 mV/cm) increased the reinnervation of the hindpaw muscles as measured by evoked electromyograms. This enhanced regeneration only occurred(More)