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Short-term facilitation and depression have a profound influence on transmission at many glutamatergic synapses, particularly during trains of stimuli. A major component of these processes is postsynaptic receptor desensitization. Both presynaptic and postsynaptic mechanisms can contribute to synaptic efficacy, but it is often difficult to define their(More)
Presynaptic group III metabotropic glutamate receptor (mGluR) activation by exogenous agonists (such as L-2-amino-4-phosphonobutyrate (L-AP4)) potently inhibit transmitter release, but their autoreceptor function has been questioned because endogenous activation during high-frequency stimulation appears to have little impact on synaptic amplitude. We(More)
At its tip (called growth cone), a neurite is elongated by the assembly of tubulin into microtubules. We present a model of elongation (extended from Van Veen and Van Pelt, Bull. Math. Biol. 56 (1994) 249-273) in which tubulin is produced in the soma and transported to the growth cone by diiusion and active transport. The model accounts for competition(More)
  • Joern R. Steinert, Cornelia Kopp-Scheinpflug, Claire Baker, R.A. John Challiss, Raj Mistry, Martin D. Haustein +4 others
  • 2008
Neuronal nitric oxide synthase (nNOS) is broadly expressed in the brain and associated with synaptic plasticity through NMDAR-mediated calcium influx. However, its physiological activation and the mechanisms by which nitric oxide (NO) influences synaptic transmission have proved elusive. Here, we exploit the unique input-specificity of the calyx of Held to(More)
An average-response model of depression at the calyx of Held, a giant glutamatergic synapse in the mammalian auditory pathway, is presented. The model is ÿt to experimentally recorded EPSC amplitudes resulting from 10 to 100 Hz presynaptic stimulation for 1 s. This data exhibits a strong depression of the EPSC amplitude. The model best ÿts the time course(More)
Neurite outgrowth (dendrites and axons) should be a stable, but easily regulated process to enable a neuron to make its appropriate network connections during development. We explore the dynamics of outgrowth in a mathematical continuum model of neurite elongation. The model describes the construction of the internal microtubule cytoskeleton, which results(More)
The formulation and numerical solution of a continuum (PDE) model of neurite elongation is presented. This model describes elongation as a function of the production, transport and (dis)assembly of tubulin into microtubules in a single growing neurite. It provides an important extension to previous ordinary diierential equation models of neurite elongation(More)
The calyx of Held is a giant glutamatergic synapse in the mammalian auditory pathway designed to ensure faithful transmission of high frequency action potential trains. Pre-and postsynaptic recordings from this synapse reveal several forms of facilitation and depression. A computational model of synaptic transmission has been developed to investigate the(More)