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- Vamsi K. Mootha, Cecilia M. Lindgren, +18 authors Leif Groop
- Nature Genetics
- 2003
DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes.… (More)
- Pontus Boström, Jun Wu, +15 authors Bruce M. Spiegelman
- Nature
- 2012
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 α… (More)
Homeostatic mechanisms in mammals respond to hormones and nutrients to maintain blood glucose levels within a narrow range. Caloric restriction causes many changes in glucose metabolism and extends… (More)
Adaptive thermogenesis is an important component of energy homeostasis and a metabolic defense against obesity. We have cloned a novel transcriptional coactivator of nuclear receptors, termed PGC-1,… (More)
- Zhidan Wu, Pere B. Puigserver, +8 authors Bruce M. Spiegelman
- Cell
- 1999
Mitochondrial number and function are altered in response to external stimuli in eukaryotes. While several transcription/replication factors directly regulate mitochondrial genes, the coordination of… (More)
Tumor necrosis factor-alpha (TNF-alpha) has been shown to have certain catabolic effects on fat cells and whole animals. An induction of TNF-alpha messenger RNA expression was observed in adipose… (More)
- Julie St-Pierre, Stavit Drori, +10 authors Bruce M. Spiegelman
- Cell
- 2006
PPARgamma coactivator 1alpha (PGC-1alpha) is a potent stimulator of mitochondrial biogenesis and respiration. Since the mitochondrial electron transport chain is the main producer of reactive oxygen… (More)
- Jun Wu, Pontus Boström, +14 authors Bruce M. Spiegelman
- Cell
- 2012
Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown… (More)
- Patrick Seale, Bryan C Bjork, +11 authors Bruce M. Spiegelman
- Nature
- 2008
Brown fat can increase energy expenditure and protect against obesity through a specialized program of uncoupled respiration. Here we show by in vivo fate mapping that brown, but not white, fat cells… (More)
- Peter Tontonoz, E. Hu, Bruce M. Spiegelman
- Cell
- 1994
Peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2) is an adipocyte-specific nuclear hormone receptor that has recently been identified as a key regulator of two fat cell enhancers.… (More)