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PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

• Vamsi K. Mootha, Cecilia M. Lindgren, +18 authors Leif Groop
• Nature Genetics
• 2003

DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes.… (More)

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

• Pere B. Puigserver, Zhidan Wu, Cheol Won Park, R. G. Graves, M. Wright, Bruce M. Spiegelman
• Cell
• 1998

Adaptive thermogenesis is an important component of energy homeostasis and a metabolic defense against obesity. We have cloned a novel transcriptional coactivator of nuclear receptors, termed PGC-1,… (More)

Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

• Zhidan Wu, Pere B. Puigserver, +8 authors Bruce M. Spiegelman
• Cell
• 1999

Mitochondrial number and function are altered in response to external stimuli in eukaryotes. While several transcription/replication factors directly regulate mitochondrial genes, the coordination of… (More)

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.

• Gökhan S Hotamisligil, N. S. Shargill, Bruce M. Spiegelman
• Science
• 1993

Tumor necrosis factor-alpha (TNF-alpha) has been shown to have certain catabolic effects on fat cells and whole animals. An induction of TNF-alpha messenger RNA expression was observed in adipose… (More)

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

• Joseph T. Rodgers, Carlos Lerín, Wilhelm Haas, Steven P Gygi, Bruce M. Spiegelman, Pere B. Puigserver
• Nature
• 2005

Homeostatic mechanisms in mammals respond to hormones and nutrients to maintain blood glucose levels within a narrow range. Caloric restriction causes many changes in glucose metabolism and extends… (More)

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

• Jun Wu, Pontus Boström, +14 authors Bruce M. Spiegelman
• Cell
• 2012

Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown… (More)

Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

• Julie St-Pierre, Stavit Drori, +10 authors Bruce M. Spiegelman
• Cell
• 2006

PPARgamma coactivator 1alpha (PGC-1alpha) is a potent stimulator of mitochondrial biogenesis and respiration. Since the mitochondrial electron transport chain is the main producer of reactive oxygen… (More)

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.

• Peter Tontonoz, Erding Hu, Bruce M. Spiegelman
• Cell
• 1994

Peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2) is an adipocyte-specific nuclear hormone receptor that has recently been identified as a key regulator of two fat cell enhancers.… (More)

PRDM16 controls a brown fat/skeletal muscle switch

• Patrick Seale, Bryan C Bjork, +11 authors Bruce M. Spiegelman
• Nature
• 2008

Brown fat can increase energy expenditure and protect against obesity through a specialized program of uncoupled respiration. Here we show by in vivo fate mapping that brown, but not white, fat cells… (More)

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

• J. Cliff Yoon, Pere B. Puigserver, +9 authors Bruce M. Spiegelman
• Nature
• 2001

Blood glucose levels are maintained by the balance between glucose uptake by peripheral tissues and glucose secretion by the liver. Gluconeogenesis is strongly stimulated during fasting and is… (More)

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