Bruce M. Altevogt

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Autism spectrum disorder is a complex developmental disorder that dramatically affects the lives of patients and their families and the broader community. The causes of autism are unknown; however, evidence increasingly suggests that a complex interplay among environmental stressors, genetic mutations, and other biological factors likely plays a significant(More)
R esearch on chimpanzees is contentious, expensive, and of increasingly limited necessity. Over the past 10 years, there have been only 110 projects involving chimpanzees sponsored by the National Institutes of Health. Close to half of these projects were used for hepatitis research; the remaining studies were in fi elds including comparative genomics,(More)
Advances in the neurosciences have placed the field in the position where it is poised to significantly reduce the burden of nervous system disorders. However, drug discovery, development, and translation for nervous system disorders still pose many unique challenges. The key scientific challenges can be summarized as follows: mechanisms of disease, target(More)
The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders established a "Grand Challenges Initiative." The goal is to help frame a broad, integrated research program that would attract substantial funding and generate additional resources to support large-scale efforts to tackle some of the most daunting but important neuroscience(More)
THE JAPANESE TSUNAMI,HAITIAN EARTHQUAKE, AND GULF Coast hurricane offered stark reminders of how vulnerable organized societies are to catastrophic events. They also show how public health emergencies— whether naturally occurring (eg, a pandemic outbreak of novel influenza) or deliberate (eg, a terrorist attack using an improvised nuclear device)—will(More)
It is only possible to achieve a resilient community and an integrated, comprehensive, and resilient health system that can respond effectively to a public health emergency through active collaboration, coordination, and shared responsibility among a broad group of public and private stakeholders and the community itself. The Institute of Medicine(More)
In response to the 2009 H1N1 influenza pandemic, public health authorities launched an ambitious vaccination program to protect tens of millions of Americans from the virus. In April and May 2010, the Institute of Medicine Forum on Medical and Public Health Preparedness for Catastrophic Events hosted a series of 3 regional workshops to examine the 2009 H1N1(More)
The Institute of Medicine's Forum on Medical and Public Health Preparedness for Catastrophic Events hosted a workshop at the request of the Federal Interagency Committee on Emergency Medical Services (FICEMS) that brought together a range of stakeholders to broadly identify and confront gaps in rural infrastructure that challenge mass casualty incident(More)
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