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VOLTAGE-GATED potassium (K+) channels display a wide variety of conductances and gating properties in vivo1–3. This diversity can be attributed not only to the presence of many K+-channel gene… (More)
- Huiyi Wang, Dennis D. Kunkel, Philip A. Schwartzkroin, Bruce L. Tempel
- The Journal of neuroscience : the official…
- 1994
Multiple voltage-gated potassium (K) channel gene products are likely to be involved in regulating neuronal excitability of any single neuron in the mammalian brain. Here we show that two closely… (More)
- Bruce L. Tempel, Nicolao Bonini, Douglas R. Dawson, William G. Quinn
- Proceedings of the National Academy of Sciences…
- 1983
Hungry fruit flies can be trained by exposing them to two chemical odorants, one paired with the opportunity to feed on 1 M sucrose. On later testing, when given a choice between odorants the flies… (More)
- Thomas L Schwarz, Bruce L. Tempel, Diane M Papazian, Yuh Nung Jan, Lily Yeh Jan
- Nature
- 1988
At least four probable components of potassium channels are encoded at the Drosophila Shaker locus, by a family of alternatively spliced transcripts. Alternative splicing may provide one mechanism of… (More)
- Diane M Papazian, Thomas L Schwarz, Bruce L. Tempel, Yuh Nung Jan, Lily Yeh Jan
- Science
- 1987
On the basis of electrophysiological analysis of Shaker mutants, the Shaker locus of Drosophila melanogaster has been proposed to encode a structural component of a voltage-dependent potassium… (More)
- Sharon L. Smart, Valeri Lopantsev, +6 authors Bruce L. Tempel
- Neuron
- 1998
Mice lacking the voltage-gated potassium channel alpha subunit, K(V)1.1, display frequent spontaneous seizures throughout adult life. In hippocampal slices from homozygous K(V)1.1 null animals,… (More)
- Valerie A. Street, Jennifer W. McKee-Johnson, Rosalia C. Fonseca, Bruce L. Tempel, Konrad Noben-Trauth
- Nature Genetics
- 1998
Hearing loss is the most common sensory deficit in humans. Because the auditory systems of mice and humans are conserved, studies on mouse models have predicted several human deafness genes and… (More)
- Joshua Jacob Zaritsky, John B Redell, Bruce L. Tempel, Thomas L Schwarz
- The Journal of physiology
- 2001
1. Ventricular myocytes demonstrate a steeply inwardly rectifying K(+) current termed I(K1). We investigated the molecular basis for murine I(K1) by removing the genes encoding Kir2.1 and Kir2.2. The… (More)
- Bruce L. Tempel, Diane M Papazian, Thomas L Schwarz, Yuh Nung Jan, Lily Yeh Jan
- Science
- 1987
Potassium currents are crucial for the repolarization of electrically excitable membranes, a role that makes potassium channels a target for physiological modifications that alter synaptic efficacy.… (More)
- Cornelia Kopp-Scheinpflug, Katja Fuchs, William R. Lippe, Bruce L. Tempel, Rudolf Ruebsamen
- The Journal of neuroscience : the official…
- 2003
The voltage-gated potassium (Kv) channel subunit Kv1.1, encoded by the Kcna1 gene, is expressed strongly in the ventral cochlear nucleus (VCN) and the medial nucleus of the trapezoid body (MNTB) of… (More)