Bruce Hettleman

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The spherical harmonic (SPHARM) description is a powerful surface modeling technique that can model arbitrarily shaped but simply connected 3D objects and has been used in many applications in medical imaging. Previous SPHARM techniques use the first order ellipsoid for establishing surface correspondence and aligning objects. However, this first order(More)
We propose a novel framework to predict pacing sites in the left ventricle (LV) of a heart and its result can be used to assist pacemaker implantation and programming in cardiac resynchronization therapy (CRT), a widely adopted therapy for heart failure patients. In a traditional CRT device deployment, pacing sites are selected without quantitative(More)
Microarray gene expression techniques have recently made it possible to offer phenotype classification of many diseases. One problem in this analysis is that each sample is represented by quite a large number of genes, and many of them are insignificant or redundant to clarify the disease problem. The previous work has shown that selecting informative genes(More)
RATIONALE AND OBJECTIVES The aim of the study is to build cardiac wall motion models to characterize mechanical dyssynchrony and predict pacing sites for the left ventricle of the heart in cardiac resynchronization therapy (CRT). MATERIALS AND METHODS Cardiac magnetic resonance imaging data from 20 patients are used, in which half have heart failure(More)
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