Bruce H. KenKnight

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Xueyi Xie2
Sirinart Kumfu1
Heath A Nier1
Siriporn C. Chattipakorn1
2Xueyi Xie
1Sirinart Kumfu
1Heath A Nier
1Siriporn C. Chattipakorn
1Pradeep S Rajendran
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Cardiovascular disease degrades the regulatory function of the autonomic nervous system. Cyclic vagus nerve stimulation (VNS) is an already FDA-approved therapy for drug-resistant epilepsy and depression, and has been shown to normalize autonomic function and improve objective measures of heart function and subjective measures of heart failure symptoms.(More)
  • Titikorn Chunchai, Bencharunan Samniang, Jirapas Sripetchwandee, Hiranya Pintana, Wanpitak Pongkan, Sirinart Kumfu +4 others
  • 2016
Vagus nerve stimulation (VNS) therapy was shown to improve peripheral insulin sensitivity. However, the effects of chronic VNS therapy on brain insulin sensitivity, dendritic spine density, brain mitochondrial function, apoptosis and cognition in obese-insulin resistant subjects have never been investigated. Male Wistar rats (n = 24) were fed with either a(More)
Using vagus nerve stimulation (VNS), we sought to determine the contribution of vagal afferents to efferent control of cardiac function. In anesthetized dogs, the right and left cervical vagosympathetic trunks were stimulated in the intact state, following ipsilateral or contralateral vagus nerve transection (VNTx), and then following bilateral VNTx.(More)
Intermittent vagal nerve stimulation (VNS) has emerged as a potential therapy to treat cardiovascular diseases by delivering electrical stimulation to the vagus nerves. The purpose of this study was to investigate the electrophysiological changes in the atrium resulting from long-term intermittent VNS therapy in the chronic myocardial infarction (MI) rat(More)
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