Bruce E. Blanchard

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OBJECTIVE Blood pressure (BP) is immediately lowered after a session of dynamic exercise, e.g. postexercise hypotension (PEH). The optimal exercise intensity needed to evoke PEH has not been established. We examined the effect of light (LITE) and moderate (MOD) exercise intensity on PEH. DESIGN Subjects were 49 men (mean +/- SEM, 43.8 +/- 1.4 years) with(More)
Limited evidence suggests renin–angiotensin–aldosterone system (RAAS) polymorphisms alter the blood pressure (BP) response to aerobic exercise training. We examined if RAAS polymorphisms influenced postexercise hypotension in men with high normal to Stage 1 hypertension. Forty-seven men (44.2±1.4 years, 145.1±1.6/85.5±1.1 mmHg) randomly completed three(More)
BACKGROUND Dietary calcium intake and the renin angiotensin system (RAS) regulate blood pressure (BP) by modulating calcium homeostasis. Despite similar BP regulatory effects, the influence of dietary calcium intake alone and combined with RAS polymorphisms on the BP response following acute aerobic exercise (i.e., postexercise hypotension) has not been(More)
The alpha-adducin Gly460Trp polymorphism alters renal sodium transport and is associated with hypertension. Despite the immediate sodium- and volume-depleting effects of aerobic exercise, the influence of the alpha-adducin Gly460Trp polymorphism on PEH (postexercise hypotension) has not been studied. In the present study we examined the effects of the(More)
We compared the genetic and clinical profile of men who lower and do not lower blood pressure (BP) after acute aerobic exercise. Volunteers were 45 men (Mean ± SEM, 43.5 ± 1.5 yr) with high BP (145.7 ± 1.5/85.7 ± 1.1 mmHg). They completed three experiments: nonexercise control and two cycle exercise sessions at 40% and 60% peak oxygen consumption, and were(More)
BACKGROUND The minimum duration of exercise needed to acutely lower blood pressure (BP) has not been established. The purpose of this study is to compare the effects of short and long duration on the BP response to a session of aerobic exercise. METHODS Subjects were 45 men (mean +/- SEM, 43.4 +/- 1.5 years) with elevated BP (144.6 +/- 1.6/85.2 +/- 1.1 mm(More)
BACKGROUND The metabolic syndrome (Msyn) affects about 40% of those with hypertension. The Msyn and hypertension have a common pathophysiology. Exercise is recommended for their treatment, prevention and control. The influence of the Msyn on the antihypertensive effects of aerobic exercise is not known. We examined the influence of the Msyn on the blood(More)
A common silent single nucleotide polymorphism (393 T>C) in exon 5 of the guanine nucleotide-binding protein system subunit (GNAS) gene associates with hypertension, and altered autonomic nervous system function and response to -blockade. We examined the effects of GNAS 393 T>C on the acute post-exercise BP response among 48 Caucasian men (mean ± SEM,(More)
Blood pressure (BP) is immediately reduced after aerobic exercise (postexercise hypotension [PEH]). Whether peak systolic BP on a maximal graded exercise stress test (GEST) relates to PEH is not known. This study examined associations between peak systolic BP on a GEST and PEH. Subjects were 50 men (mean +/- SEM age 43.8 +/- 1.3 years) with elevated BP(More)
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