Bruce D. Davies

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The current case study attempted to document the contemporary demands of elite rugby union. Players (n = 2) were tracked continuously during a competitive team selection game using Global Positioning System (GPS) software. Data revealed that players covered on average 6,953 m during play (83 minutes). Of this distance, 37% (2,800 m) was spent standing and(More)
We have used quantitative zymography to measure levels of the type IV collagenases matrix metalloproteinase (MMP)-9 and MMP-2 in 42 biopsies of transitional cell carcinoma and in 7 biopsies of normal bladder. Mean levels of MMP-9 were significantly higher in tumor compared with normal samples (P = 0.08). Levels of MMP-9 and active MMP-2 increased with tumor(More)
We have examined the effect of a synthetic low-molecular-weight matrix metalloproteinase inhibitor, [4-(N-hydroxyamino)-2R-isobutyl-3S- (thiopen-2-ylthiomethyl)-succinyl]-L-phenylalanine-N-meth yla mide (BB-94), on human ovarian carcinoma xenografts growing in nude mice. The xenografts grew as thick intraperitoneal mucinous ascites containing free-floating(More)
Free radicals or oxidants are continuously produced in the body as a consequence of normal energy metabolism. The concentration of free radicals, together with lipid peroxidation, increases in some tissues as a physiological response to exercise – they have also been implicated in a variety of pathologies. The biochemical measurement of free radicals has(More)
Intense exercise is known to cause temporary impairments in immune function. Few studies, however, have investigated the effects of intense competitive exercise on immunoendocrine variables in elite team sport athletes. The aim of this study was to evaluate the time course of changes in selected immunoendocrine and inflammatory markers following an(More)
PURPOSE To examine the relationship between upper respiratory illness (URI) incidence with changes in mucosal immunity (saliva immunoglobulin A (s-IgA) and saliva lysozyme (s-Lys)) and training load (TL) in a squad of elite rugby union players. METHODS Timed resting morning saliva samples were taken from players (n = 31) at preselected time points for 11(More)
The purpose of this study was to investigate agility performance of rugby players using various intensity running tests. A further aim was to investigate if any differences existed between playing positions in relation to agility performance. Nineteen subelite players (mean +/- SD age, 23.0 +/- 5.4 years) participated in the study. Players underwent(More)
In order to understand the ability of human ovarian cancers to degrade the basement membrane, we have studied the localization and activity of matrix metalloproteases (MMPs) 2 and 9, using in situ hybridization and quantificative zymography on sequential sections of tumor biopsies. We have related these data to expression of some of the controlling elements(More)
Reactive oxygen species (ROS) have been implicated in the cellular membrane damage and postoperative morbidity associated with obligatory ischemia-reperfusion (I-R) during vascular surgery. Thus, a clinical study was undertaken to evaluate the effects of ascorbate prophylaxis on ROS exchange kinetics in 22 patients scheduled for elective abdominal aortic(More)
PURPOSE The purpose of this study was to examine the upper-body contribution via handgrip to power profiles and blood lactate concentrations during high-intensity cycle ergometry. METHODS Nine trained male subjects each completed a 20-s high-intensity cycle ergometer test twice, in a random manner, using two protocols, with a handgrip (WG), and without(More)