Bruce C. Black

Learn More
The yellow (y) gene of Drosophila is required for the formation of black melanin and its deposition in the cuticle. We have studied by immunohistochemical methods the temporal and spatial distribution of the protein product of the y gene during embryonic and pupal development and have correlated its expression with events of cuticle synthesis by the(More)
The major adenovirus core protein (P.VII) binds to various species of duplex and single-stranded DNA molecules as a linear function of P.VII concentration. P.VII progressively condenses 32S Ad2 DNA into rapidly sedimenting forms having an S value of around 2,280. P.VII does not coat DNA like cytochrome C, instead DNA-protein beads are visualized in the(More)
A limited access 'keyhole' cochlear implantation (CI) surgical technique is presented. The surgery employs a 15-18 mm diameter C-incision on the rear of the auricle. The implant is retained in a snug pericranial pocket. A bony retention well is avoided. Minimal mastoid cell clearance is used. The surgery is brief, atraumatic and well suited to small infant(More)
The major pathway leading to adult cuticle melanization in Drosophila melanogaster has been investigated by a combination of biochemical and genetic approaches. By comparing catecholamine pools in newly emerged flies and in frass (excreta) collected 1 to 4 days after eclosion from wild type with those obtained from several pigmentation mutants, the major(More)
BACKGROUND Paediatric cochlear implantation (PCI) requires complex case evaluation and counselling, surgical intervention, and habilitation. Outcomes vary and many cases have sub-optimal outcomes as a result of a broad spectrum of adverse influences. OBJECTIVE To systematically review the literature to identify research papers that indicate a demonstrated(More)
INTRODUCTION Past cochlear implantation (CI) techniques have included a variety of soft tissue and bony trauma to place and stabilize the implant body. Despite minimalist approaches, the surgery invites further refinement. MATERIALS AND METHODS A restricted access "keyhole" CI technique was developed through a series of 547 cases undertaken from 1997. The(More)
OBJECTIVE To review and modify past methods of reporting ossiculoplasty results, improve analysis, standardize presentation formats, and achieve greater veracity of the reported outcomes. STUDY DESIGN A review of past and present evaluation methods. BACKGROUND Past ossiculoplasty evaluation methods have been often poorly comparable, based on(More)
Phenol oxidase, a complex enzyme, plays a major role in the processes of sclerotization and melanization of cuticle in insects. Several loci have been reported to affect levels of phenol oxidase activity, but to date only one structural locus has been identified [Dox-3F (2-53.1+)]. Recently isolated Dox-A2 mutations (2-53.9) are recessive, early larval(More)
The dopa decarboxylase gene (Ddc) is located in a very dense cluster of genes many of whose functions appear to be related to the physiological role of dopa decarboxylase (DDC) in catecholamine metabolism. In Drosophila melanogaster catecholamine metabolism is involved in the production of neurotransmitters and in the synthesis of cross-linking agents for(More)
This paper describes implemented methods for characterizing a 5-bit programmable dispersion matrix (PDM) that is built to control a two-channel Receive beamformer in the 1550 nm region. The architecture of the PDM, is based on an array of 5 delay lines each having two spliced fiber Bragg gratings. Phase measurements for 32 possible delay configurations of(More)