Bruce Briggs

Learn More
BACKGROUND Cytomegalovirus (CMV) is the primary viral cause of complications in transplant recipients. We sought to understand the mechanisms of its dissemination and induction of vascular disease, which may lead to transplant complications. Sialyl Lewis(x) (sLe(x)) and Lewis(x) (Le(x)) are known for their roles in mediating cell adhesion and as(More)
Baseline immunological data on the chinchilla were obtained, and a detailed method for purification of each immunoglobulin is described. Antiserum to each chinchilla immunoglobulin was made by immunizing rabbits with immunoglobulins purified from serum and colostrum. The main classes of serum immunoglobulins in the chinchilla are G, A, and M, similar to(More)
Apolizumab (Hu1D10), a humanized monoclonal anti- Human leukocyte antigen -DR beta-chain antibody, mediates apoptosis of chronic lymphocytic leukemia (CLL) cells in vitro. We conducted a phase I/II dose-escalation study of thrice-weekly apolizumab (1.5, 3.0, 5.0 mg/kg/dose) for 4 weeks in relapsed CLL. Two of six patients at 5.0 mg/kg/dose developed(More)
The computer news editing program is designed to perform the following functions: (1) it will input automatically those stories from the AP Teletypesetter tape which the editor wishes to use; (2) it will make additions and deletions in these stories according to instructions received from the editor; (3) it will attempt to “edit,” i.e. cut from(More)
BACKGROUND Intercellular adhesion molecule-1 (ICAM-1) is strongly induced under inflammatory conditions associated with allograft rejection, thereby promoting leukocyte recruitment and activation at the site of inflammation. Enhancement of ICAM-1 expression can also be the result of viral infection, in particular human cytomegalovirus (CMV), a frequent(More)
In an earlier study the authors demonstrated that formalin-killed Hemophilus influenzae induces serous-type middle ear effusion in chinchillas and provides an excellent model for the study of human otitis media with effusion. The present study was initiated to evaluate the morphologic and histologic changes that occur in the middle ear after injection of(More)