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BACKGROUND AND PURPOSE A significant number of patients with aneurysmal subarachnoid hemorrhage are active smokers and at risk for acute nicotine withdrawal. There is conflicting literature regarding the vascular effects of nicotine and theoretical concern that it may worsen vasospasm. The literature on the safety of nicotine replacement therapy and its(More)
The Silent Cerebral Infarct Multicenter Transfusion (SIT) Trial is a multi-institutional intervention trial in which children with silent cerebral infarcts are randomized to receive either blood transfusion therapy or observation (standard care) for 36 months. The SIT Trial is scheduled to enroll approximately 1,880 children with sickle cell disease from 29(More)
Persons who abuse or are dependent on opioids are at elevated risk for arrest. Co-occurring behavioral health problems may exacerbate that risk, although the extent of any such increase has not been described. This study examines such risk factors among 40,238 individuals with a diagnosis of opioid abuse or dependence who were enrolled in the Massachusetts(More)
Scripture quotations marked NKJV are taken from the New King James Version. (No citation is given for Scripture text that is exactly the same wording in all three versions—NIV, NKJV, and NRSV.) Scripture quotations marked KJV are taken from the Holy Bible, King James Version.et al.]. p. cm. — (Life application Bible commentary) Includes bibliographical(More)
Prompt administration of anti-toxin reduces mortality following Corynebacterium diphtheriae infection. Current treatment relies upon equine diphtheria anti-toxin (DAT), with a 10% risk of serum sickness and rarely anaphylaxis. The global DAT supply is extremely limited; most manufacturers have ceased production. S315 is a neutralizing human IgG1 monoclonal(More)
BACKGROUND Dantrolene is neuroprotective in animal models and may attenuate cerebral vasospasm (cVSP) in human aneurysmal subarachnoid haemorrhage (aSAH). We evaluated safety, feasibility and tolerability of intravenous dantrolene (IV-D) in patients with aSAH. METHODS In this single-centre, randomised, double blind, placebo-controlled trial, 31 patients(More)
Background. Morbidity and mortality from toxigenic Corynebacterium diphther-iae is greatly reduced by prompt administration of anti-toxin. Current treatment relies upon equine-derived antibodies to diphtheria toxin (Diphtheria Anti-Toxin [DAT]) that carry the risk of a severe allergic reaction. The global supply of DAT is extremely limited as most(More)
OBJECTIVES The goal of this project was to develop the first disease-specific instrument for the evaluation of quality of life in chronic pancreatitis. METHODS Focus groups and interview sessions were conducted, with chronic pancreatitis patients, to identify items felt to impact quality of life which were subsequently formatted into a paper-and-pencil(More)
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