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Actin depolymerizing factor (ADF) occurs naturally in two forms, one of which contains a phosphorylated Ser and does not bind G-actin or depolymerize F-actin. Removal of this phosphate in vitro by alkaline phosphatase restores full F-actin depolymerizing activity. To identify the phosphorylation site, [32P]pADF was purified and digested with endoproteinase(More)
  • Bruce Agnew
  • Bulletin of the World Health Organization
  • 2002
Twenty years after physicians first spotted the immune deficiency disease that became known as AIDS, the state of the worldwide AIDS epidemic is stirring both dismay and hope, judging from the latest AIDS Epidemic Update released on 28 November by the Joint United Nations Programme on HIV/ AIDS (UNAIDS) and WHO. InEastern Europe andCentral Asia, HIV(More)