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BACKGROUND There is an ongoing debate about the best way to classify eating disorders. This study examined potential subtypes of bulimia nervosa. METHOD Latent class analysis (LCA) was used to identify subtypes of bulimic symptomatology, utilizing data from 234 respondents in a cohort of black and white young women ( n =2054). Participants were(More)
BACKGROUND The role of physical activity in preventing obesity during adolescence remains unknown. We examined changes in activity in relation to changes in body-mass index (BMI) and adiposity in a cohort of 1152 black and 1135 white girls from the USA, who were followed up prospectively from ages 9 or 10 to 18 or 19 years. METHODS BMI and sum of skinfold(More)
CONTEXT Insulin resistance has been proposed as one of the causes of poor glycemic control in overweight/obese youth with type 1 diabetes (T1D). However, the role of adjunctive metformin, an insulin sensitizer, on glycemic control in these patients is unclear. OBJECTIVE To compare the effect of metformin vs. placebo on hemoglobin A1c (HbA1c), total daily(More)
Social stress is frequently used as a model for studying the neuroendocrine mechanisms underlying stress-induced behavioral inhibition, depression, and fear conditioning. It has previously been shown that social subordination may result in increased glucocorticoid release and changes in brain signaling systems. However, it is still an open question which(More)
BACKGROUND Opioid analgesia is commonly used during neonatal intensive care. We undertook the Neurologic Outcomes and Pre-emptive Analgesia in Neonates (NEOPAIN) trial to investigate whether pre-emptive morphine analgesia decreases the rate of a composite primary outcome of neonatal death, severe intraventricular haemorrhage (IVH), and periventricular(More)
OBJECTIVE Second-generation, or atypical, antipsychotics effectively treat psychiatric illness in children and adolescents. However, weight gain and abnormalities in insulin sensitivity, including diabetes, complicate this therapy. METHOD A 16-week double-blind, placebo-controlled trial was conducted to evaluate the effectiveness of metformin in managing(More)
An efficient algorithm for partitioning the range of a continuous variable to a discrete Ž. number of intervals, for use in the construction of Bayesian belief networks BBNs , is presented here. The partitioning minimizes the information loss, relative to the number of intervals used to represent the variable. Partitioning can be done prior to BBN(More)
OBJECTIVE To determine whether the frequency of family meals in childhood is associated with positive health outcomes in adolescence through the mediating links of increased family cohesion and positive coping skills. DESIGN Data were obtained from the National Heart, Lung, and Blood Institute Growth and Health Study (NGHS), a 10-year longitudinal study(More)
BACKGROUND Little is known about the extent to which negative life events predict depressive symptoms in ethnically diverse groups or whether this relationship is proximal or enduring. METHOD The relationship between negative life events in adolescence and depressive symptoms in young adulthood was studied in a sample of over 1300 black and white female(More)
OBJECTIVE Metformin was assessed as a treatment for weight gain in children taking olanzapine, risperidone, quetiapine, or valproate. METHOD The subjects were 19 patients aged 10-18 years; 15 were white and four were black, and there were 12 boys and seven girls. In a 12-week open-label study, each patient received metformin, 500 mg t.i.d. Changes in(More)