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BACKGROUND Resistance to carbapenems among Acinetobacter baumannii and Klebsiella pneumoniae presents a serious therapeutic and infection control challenge. We describe the epidemiology and genetic basis of carbapenem resistance in A. baumannii and K. pneumoniae in a six-hospital healthcare system in Northeast Ohio. METHODS Clinical isolates of A.(More)
As the current Zaire ebolavirus epidemic advances, infected patients may present or be transferred to medical settings with advanced management capabilities. Critical care units that may receive such patients must prepare to render such care while protecting staff from infection. Although providing supportive care to a critically ill patient with Ebola(More)
Intervention: Universal decolonization in all patients using intranasal mupirocin, twice daily for 5 days, plus daily bathing with chlorhexidine-impregnated cloths during ICU stay (29 ICUs, 26 024 patients during intervention); MRSA screening at ICU admission, with targeted decolonization in patients with MRSA colonization or infection using 5 days of(More)
PURPOSE OF REVIEW The aim is to discuss the epidemiology of infections that arise from contaminated water in healthcare settings, including Legionnaires' disease, other Gram-negative pathogens, nontuberculous mycobacteria, and fungi. RECENT FINDINGS Legionella can colonize a hospital water system and infect patients despite use of preventive(More)
Genotyping methods are essential to understand the transmission dynamics of Acinetobacter baumannii. We examined the representative genotypes of A. baumannii at different time periods in select locations in Ohio, using two rapid automated typing methods: PCR coupled with electrospray ionization mass spectrometry (PCR/ESI-MS), a form of multi-locus sequence(More)
BACKGROUND Acinetobacter species are well-known causes of health care-associated infections. The longitudinal epidemiology of this species in the hospital setting is poorly understood. A sudden, persistent increase in multidrug-resistant (MDR) A baumannii infections occurred beginning in June 2006 at Temple University Hospital in Philadelphia. An analysis(More)