Brittany Anderton

Learn More
the present ")Cd n.m.r. data suggest that phospholipase C contains three classes of metal binding site. Type I, which is a single site buried somewhat in the structure, has a marked preference for Zn2+. This site has the highest affinity for divalent metal ions. Type I1 is a single site of somewhat lower affinity for divalent metal ions and shows a lesser(More)
Abnormal centrosome and centriole numbers are frequently detected in tumor cells where they can contribute to mitotic aberrations that cause chromosome missegregation and aneuploidy. The molecular mechanisms of centriole overduplication in malignant cells, however, are poorly characterized. Here, we show that the core SKP1-cullin-F-box component cullin 1(More)
Serial sections of brains of eight cases with Alzheimer's disease were stained by methods utilising silver and three different monoclonal antibodies. The numbers of Alzheimer's neurofibrillary tangles (NFT) were counted in the silver stained sections and compared with the numbers detected by three monoclonal anti-NF antibodies: RT97, BF10 and 8D8. The(More)
An antiserum to pure glutamate decarboxylase (GAD) when incubated with rat cortical synaptosomes in the presence of complement caused release of 33-53% of lactate dehydrogenase (LDH) and 22-41% of total GAD. In addition most of the gamma-aminobutyrate (GABA) present was released. Anti-GAD antiserum alone, or complement alone, were without action. The(More)
Monoclonal antibodies were used to explore the relationship between two similarly sized microtubule-associated proteins (MAPs), MAP1x and MAP5. Although the proteins detected by anti-MAP1x and anti-MAP5 co-migrate in SDS-polyacrylamide gels, the patterns of antigenic proteolytic fragments (epitope maps) derived from them were completely different. The(More)
  • 1