Brigitte Le Roux

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AKlebsiella pneumoniae strain having mobilization “helper” potential has been isolated from the river Rhine. Analysis of the transconjugants resulting from the mobilization of nonconjugative pBR-type plasmids and RSF1010 derivatives showed that the transfer-helper capacity of theK. pneumoniae strain is related to the presence of a Tn3-like transposable(More)
p-Aminobenzoic acid (PABA) is an important precursor in the bacterial biosynthetic pathway for folate enzymes. This biosynthesis requires three separate proteins: PabA, PabB, and PabC. Together PabA and PabB convert glutamine and chorismate to glutamate and 4-amino-4-deoxychorismate. This aminochorismate is subsequently transformed to PABA by PabC. In this(More)
p-Aminobenzoate synthesis in Escherichia coli requires three enzymes, PabA, PabB, and PabC, acting respectively as glutaminase, chorismate aminase, and 4-amino-4-deoxychorismate aromatase. PabA requires stoichiometric amounts of PabB to display glutaminase activity. PabA has conserved cysteine (C79), histidine (H168), and glutamate (E170) residues that have(More)
In a Euclidean hierarchical ascending clustering (HAC,Ward’s method), the usual method for allocating a supplementary object to a cluster is based on the geometric distance from the object-point to the barycenter of the cluster. The main drawback of this method is that it does not take into consideration that clusters differ as regards weights, shapes and(More)
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