Brieanna R. Brown

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  • Michael F Brown, Curriculum Vitae, J Clarence, Karcher Lecturer, Richard, Patricia Wood Lecturer +198 others
  • 2016
I am active in professional societies and continue to coordinate a number of society award nominations on behalf of my scientific colleagues. I review ~25–30 papers for scientific journals each year as well as research grants for various organizations and participate on various review panels. The Brown group carries out fundamental research in molecular(More)
  • Michael F Brown, Curriculum Vitae, J Clarence, Karcher Lecturer, Richard, Patricia Wood Lecturer +202 others
  • 2016
I am active in professional societies and coordinate a number of society award nominations for scientific colleagues. I am Associate Editor of the Biophysical Journal and review ~20–30 scientific papers each year as well as research grants for various organizations and participate on various review panels. Award of Biophysical Society-3 nominations (all(More)
INTRODUCTION Systemic rheumatic conditions are often accompanied by intraocular inflammatory disease (termed uveitis). Despite the frequent manifestation of uveitis with arthritis, very little is understood of the underlying mechanisms that mediate the eye's susceptibility to disease. The genetically susceptible SKG mouse strain develops arthritis that(More)
Fanconi anemia hematopoietic stem cells display poor self-renewal capacity when subjected to a variety of cellular stress. This phenotype raises the question of whether the Fanconi anemia proteins are stabilized or recruited as part of a stress response and protect against stem cell loss. Here we provide evidence that FANCL, the E3 ubiquitin ligase of the(More)
An abbreviated version of Rotter's Locus of Control (LOC) Scale was administered to 437 elderly subjects living in a variety of settings in an urban community. The group (n = 199) which scored below the median (internal orientation) was compared with the group (n = 238) which scored at or above the median (external orientation) on an array of 37 cognitive(More)
Halothane (1,1,1-trifluoro-2-bromo-2-chloroethane) is a safe, clinically useful inhalation anesthetic. Rare, unpredictable cases of liver necrosis have been reported following its use. Although the mechanism of this reaction in man is unknown the most plausible is biotransformation to reactive intermediates compounds. The oxidative metabolism of halothane(More)
In this manuscript we report our attempts to determine if 14C-halothane or its metabolites interact with DNA. Three bioactivation systems were used: in vitro microsomal incubations, isolated hepatocytes, and in vivo administration. Even though we used optimal conditions for bioactivation, no significant covalent binding of 14C to DNA was observed. Slight(More)
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