Bridget M. Ogilvie

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Most of the organisms of the phylum Nematoda are free living, but some are animal or plant parasites of major importance to man. During their life cycle all nematodes undergo a series of moults in which they shed an external cuticle, consisting of an outermost membrane-like layer of unknown composition and a series of fibrillar layers similar to collagens.(More)
Infective larvae of trichinella spiralis were surface-labelled with radioactive iodine, and the products were characterized biochemically and immunochemically. The labelled material was restricted to two basic subunits: a lentil lectin-adherent glycoprotein (GP), mol. wt 47K, and a lentil lectin-nonadherent protein fraction (P), mol. wt 55K. Both of these(More)
The surface antigens of Toxocara canis infective larvae have been identified by radio-iodination and compared with the excretory-secretory (ES) products released by the larvae in vitro. Common antigens, of molecular weight 32 000 and 120 000 are found on the larval surface, in the ES material and in culture supernatant following surface iodination of living(More)
T. brucei infection in mice causes generalized immunosuppression with multiple changes in the cells of the lymphoid tissue. Loss of B cell responsiveness to antigens and mitogens, and the induction of suppressive T-cells and macrophages, have been previously reported (Hudson, Byner, Freeman & Terry, 1976; Corsini, Clayton, Askonas & Ogilvie, 1977;(More)
The peripheral blood leucocyte (PBL) response to infection with two species of the intestinal protozoan Eimeria shows a remarkably similar pattern in both rats and chickens. Like resistance to these parasites, the PBL response to reinfection is species-specific and it coincides with the inhibition of development of the parasite and with cellular(More)
Antibody responses were measured in a volunteer infected four times with Necator americanus over a 27-month period. The main source of antigen was culture fluid in which living adult N. americanus had been maintained for several days. Antibodies to worm acetylcholinesterase and IgE antibodies were detected only with this material, but antibodies were(More)
Surface antigens of three stages of three species of the filarial nematode genus Brugia have been analysed by radio-iodination and immunoprecipitation. These surface antigens have been shown to be characteristic for each stage by polyacrylamide gel electrophoresis. For example, infective larvae and adult worms have relatively complex patterns while(More)
Previous reports have described profound effects on the function of the lymphoid system, especially the spleen, in mice infected with Trypanosoma brucei. This study provides further evidence of major change in the cell populations of the blood, peritoneum, and bone marrow, but shows that at least some of the stem cells of the bone marrow survive the damage(More)