Bridget M. Dunne

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AIMS/BACKGROUND Metastatic disease in patients with ocular melanoma is resistant to chemotherapy. One of the main mechanisms of modulating multidrug resistance is the expression of the multidrug resistance gene 1 (MDR1) product (p-glycoprotein) by tumour cells. The purpose of this study was to evaluate the frequency of expression of the MDR1 gene in ocular(More)
Metastatic uveal melanoma is profoundly chemoresistant and has a very poor outcome. We have previously shown that the MDR1 gene and its gene product P-glycoprotein (P-gp), which are known to cause drug resistance in cancer cells, are expressed in ocular melanoma. Overexpression of MDR1 has been associated with a poor survival in some tumor types treated by(More)
Conservation biologists generally follow one of two paradigms, one emphasizes the ultimate causes of species extinction, the other, the proximate causes. The two paradigms must be integrated to fully realize species recovery, however, there are practical limitations to doing so in most situations involving endangered species. In particular, it is difficult(More)
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