Briar McLeod

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A retrospective review of over-anticoagulated patients with critical international normalized ratios (INRs) was undertaken in a large outpatient laboratory. In the six-month study period, 85 prothrombin times (PTs) were identified with an INR of > or = 6.0, an overall incidence of elevated PTs of 0.2% or two per 1,000 INR tests. Complete follow-up data was(More)
BACKGROUND Malignant bowel obstruction (MBO) is common in patients with advanced cancer. AIM To perform a phase II study to assess the feasibility of conducting a phase III trial investigating the therapeutic value of gastrografin in MBO. METHODS Randomized double-blinded placebo-controlled feasibility study. Participants received 100 mL of either(More)
A series of experiments was designed to assess the effect of a treatment protocol (U-synch) for inducing oestrus and ovulation out of the breeding season in adult ewes and ewe lambs. The protocol consisted of a 7-day treatment with an intravaginal progesterone-releasing device (IPRD), administration of GnRH at IPRD insertion on Day 0, and equine chorionic(More)
Propofol has been used to induce and, by continuous infusion, maintain, surgical anaesthesia in 18 patients undergoing day case gynaecological surgery. All patients received fentanyl 1.5 micrograms/kg two minutes before induction. Propofol in a dose of 2.5 mg/kg provided a smooth induction with an acceptably low incidence of pain on injection, although the(More)
The National Committee for Clinical Laboratory Standards (NCCLS) recommends that all coagulation studies be done on a specimen from the tube drawn second or later. For patients receiving long-term anticoagulant therapy, this may require that the first tube of blood drawn be discarded for each prothrombin evaluation. In a prospective study we compared the(More)
AIM To explore the impact of bariatric surgery on health-related quality of life (HRQoL). METHODS An audit of patients referred for bariatric procedures. Patients completed Short Form-36 questionnaires at their first pre-operative clinic and at their 6-month follow up appointment after surgery. SF-36 scores were compared with standard parametric tests. (More)
Opioids may depress respiration and contribute to airway obstruction after adenotonsillectomy for obstructive sleep disorder. We compared the respiratory and analgesic effects of nalbuphine, which has a ceiling effect for respiratory depression, and pethidine in 90 children (aged 2-12 years) with a history of obstructive sleep disorder undergoing(More)
Thirty unpremedicated patients for day-case surgery were anaesthetized with 2.5 mg kg-1 of a new formulation of I.C.I. 35868 (propofol: Diprivan--I.C.I.) in a lipid emulsion. An initial bolus of fentanyl (1-1.5 micrograms kg-1) was given. Anaesthesia was maintained with intermittent boluses of propofol (1 mg kg-1) with no other agent added. The significant(More)
The diagnosis of venous thromboembolic disease remains a difficult challenge. Chest radiography, ventilation/perfusion lung scanning, noninvasive leg testing, and pulmonary angiography were evaluated with regard to sensitivity, specificity, positive and negative predictive values. The need for treatment, observation, or serial testing with respect to risks(More)
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