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Neuronal connectivity is established by the axo-dendritic polarity, correct guidance and targeting of neurons. Unlike for axons, the mechanisms responsible for directed outgrowth of dendrites are not well understood. Using single-cell labeling, we describe specific guidance defects in dendrites of identified neurons in frazzled, robo, netrin and(More)
Data from large prospectively collected anterior cruciate ligament (ACL) cohorts are being utilized to address clinical questions regarding ACL injury demographics and outcomes of ACL reconstruction. These data are affected by patient and injury factors as well as surgical factors associated with the site of data collection. The aim of this article is to(More)
We demonstrate a system for flexible querying against text that has been annotated with the results of NLP processing. The system supports self-overlapping and parallel layers, integration of syntactic and ontological hierarchies, flexibility in the format of returned results, and tight integration with SQL. We present a query language and its use on(More)
Context: Anterior cruciate ligament (ACL) reconstruction rehabilitation has evolved over the past 20 years. This evolution has been driven by a variety of level 1 and level 2 studies. Evidence Acquisition: The MOON Group is a collection of orthopaedic surgeons who have developed a prospective longitudinal cohort of the ACL reconstruction patients. To(More)
There are a variety of operative and non operative modalities that can be used to address patellofemoral pain secondary to arthrosis. Patellofemoral Arthroplasty (PFA) is one of the latest alternatives designed to address the pain caused by severe, isolated osteoarthritis (OA) of the patellofemoral joint (PFJ). in the past, PFA has experienced variable(More)
Fully automated segmentation of computed tomography (CT) images remains a challenge for musculoskeletal researchers. The surfaces generated from image segmentations are valuable for surgical evaluation and planning. Previously, we demonstrated the expectation maximization (EM) algorithm as a semi-automated method of bone segmentation from CT images. In this(More)
HYPOTHESIS The purpose of this cross-sectional study is to determine whether the duration of symptoms influences the features seen in patients with atraumatic, full-thickness rotator cuff tears. Our hypothesis is that an increasing duration of symptoms will correlate with more advanced findings of rotator cuff tear severity on magnetic resonance imaging,(More)
BACKGROUND The Snyder classification scheme is the most commonly used system for classifying superior labral injuries. Although this scheme is intended to be used for arthroscopic visual classification only, it is thought that other nonarthroscopic historical variables also influence the classification. PURPOSE This study was conducted to evaluate the(More)
BACKGROUND The management of meniscus tears identified at the time of primary anterior cruciate ligament (ACL) reconstruction is highly variable and includes repair, meniscectomy, and nontreatment. HYPOTHESIS/PURPOSE The purpose of this study was to determine the reoperation rate for meniscus tears left untreated at the time of ACL reconstruction with a(More)