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BACKGROUND Paralysis or amputation of an arm results in the loss of the ability to orient the hand and grasp, manipulate, and carry objects, functions that are essential for activities of daily living. Brain-machine interfaces could provide a solution to restoring many of these lost functions. We therefore tested whether an individual with tetraplegia could(More)
OBJECTIVE In a previous study we demonstrated continuous translation, orientation and one-dimensional grasping control of a prosthetic limb (seven degrees of freedom) by a human subject with tetraplegia using a brain-machine interface (BMI). The current study, in the same subject, immediately followed the previous work and expanded the scope of the control(More)
Brain-computer interface (BCI) technology aims to help individuals with disability to control assistive devices and reanimate paralyzed limbs. Our study investigated the feasibility of an electrocorticography (ECoG)-based BCI system in an individual with tetraplegia caused by C4 level spinal cord injury. ECoG signals were recorded with a high-density(More)
The peripheral nervous system carries sensory and motor information that could be useful as command signals for function restoration in areas such as neural prosthetics and functional electrical stimulation (FES). Nerve cuff electrodes provide a robust and safe technique for recording nerve signals. However, a method to separate and recover signals from(More)
The peripheral nerves of an amputee's residual limb still carry the information required to provide the robust, natural control signals needed to command a dexterous prosthetic limb. However, these signals are mixed in the volume conductor of the body and extracting them is an unmet challenge. A beamforming algorithm was used to leverage the spatial(More)
OBJECTIVES Pain due to peripheral neuropathy is extremely difficult to treat as drugs often become less and less effective over the course of a patient's life. In order to augment such treatments, electrical stimulation has become relatively common, in the form of transcutaneous electrical nerve stimulation, peripheral nerve stimulation, and spinal cord(More)
Our research group recently demonstrated that a person with tetraplegia could use a brain-computer interface (BCI) to control a sophisticated anthropomorphic robotic arm with skill and speed approaching that of an able-bodied person. This multiyear study exemplifies important principles in translating research from foundational theory and animal experiments(More)
PURPOSE Conventional ultrasound systems operate at 6 to 9 MHz and serve as the standard of care to guide prostate biopsies. We present a protocol using a novel high resolution (29 MHz) transrectal prostate micro-ultrasound system. This protocol includes a scoring system to assess the risk of prostatic carcinoma and enable real-time targeted biopsies. (More)
CONTEXT Spinal cord injury (SCI) results in a loss of function and sensation below the level of the lesion. Neuroprosthetic technology has been developed to help restore motor and autonomic functions as well as to provide sensory feedback. FINDINGS This paper provides an overview of neuroprosthetic technology that aims to address the priorities for(More)
Used clinically since Penfield and Jasper's pioneering work in the 1950's, electrocorticography (ECoG) has recently been investigated as a promising technology for brain-computer interfacing. Many researchers have attempted to analyze the properties of ECoG recordings, including prediction of optimal electrode spacing and the improved resolution expected(More)