Brian Vickery

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This paper describes the overall architecture and design aspects of a hybrid relational and XML database system called System RX. We believe that such a system is fundamental in the evolution of enterprise data management solutions: XML and relational data will co-exist and complement each other in enterprise solutions. Furthermore, a successful XML(More)
A new class of parathyroid hormone-related protein (PTHrP) analogs has been developed that causes a rapid gain in both trabecular and cortical bone in models of osteopenia. This study investigates the efficacy of the PTHrP analog, RS-66271 ([MAP(1-10)]22-31 hPTHrP(1-34)-NH(2)), as systemic therapy for impaired bone healing in corticosteroid-treated rabbits.(More)
The incorporation of Arg residues into position 6 of gonadotropin releasing hormone antagonists had resulted in compounds with increased in vivo potency but also made these analogues potent mast cell degranulators. We have focused on the substitution of position 8 by hArg(R)2 (NG,NG'-dialkylhomoarginine) substitutions, based on the hypotheses that the(More)
In order to study the function of a gonadotropin-releasing hormone (GnRH) in pregnancy, a GnRH antagonist was administered to pregnant baboons (35 to 45 days' gestation) over 7 days. A marked suppression of progesterone, estrone, and estradiol was observed during treatment. In two animals, estrogens were still suppressed later in pregnancy (days 95 to 116),(More)
information representation and retrieval in the digital age asist monograph series What to say and what to do when mostly your friends love reading? Are you the one that don't have such hobby? So, it's important for you to start having that hobby. You know, reading is not the force. We're sure that reading will lead you to join in better concept of life.(More)
RS-30199 has been shown previously to have atypical interactions at 5-HT1A receptors. RS-30199 and RS-64459, an analogue of buspirone with a buspirone side chain, were compared with the classic, partial agonist at 5-HT1A receptors, 8-hydroxy-2 (di-n-propylamino) tetralin (8-OH-DPAT) and buspirone. At human (h) 5-HT1A receptors in CHO cells, RS-30199-193(More)
The role of the pituitary gonadotrophins in controlling luteal function in the stumptailed macaque has been investigated by examining profiles of serum concentrations of LH, FSH, progesterone and oestradiol in daily blood samples from 13 monkeys during the menstrual cycle, and in blood samples taken at hourly intervals between 09.00 and 21.00 h on different(More)