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Direct injection of dopaminergic agonist apomorphine into the lateral cerebral ventricle, the preoptic anterior hypothalamus, the caudate-putamen complex, or the globus pallidus caused hypothermia, decreased metabolism and cutaneous vasoconstriction at ambient temperature (Ta) 8 and 22 degrees C, and hyperthermia and cutaneous vasoconstriction in the rat at(More)
Both beta-endorphin and clonidine proved to have statistically significant analgesic activity (increase in latency to hind-paw lick in hot plate test) in rats. Furthermore, the pain inhibition induced by beta-endorphin and clonidine could be antagonized by prior treatment of animals with either naloxone (a narcotic antagonist) or the depletors of central(More)
In the rat, elevating dopamine content in corpus striatum with electrical stimulation of substantia nigra or direct administration of apomorphine (50–200μg) into the lateral cerebral ventricle or apomorphine (2–10μg) into the caudate-putamen complex decreased pain sensitivity (as shown by an increase in the latency to hind-paw lick in the hot plate test).(More)
Seventy-nine units in the striatal region were examined in 48 urethan-anesthetized rats. When these units were classified by their thermal responsiveness, proportions of the cold-responsive, warm-responsive, and thermally unresponsive units were 25.4, 35.4, and 39.2%, respectively, of the total units tested. Either microiontophoretically or systemically(More)
1. Either electrical stimulation of midbrain raphe nuclei or administration of 5-hydroxytryptamine (5-HT; serotonin) into the preoptic anterior hypothalamus caused hypothermia in conscious rats at ambient temperatures (T a) of both 8° C and 22°C. The hypothermia was due to decreased metabolic heat production at T a=8°C, while at T a=22°C the hypothermia was(More)
The changes in rectal temperature, metabolic rate, cutaneous temperatures and respiratory evaporative heat loss produced by an injection of a bacterial endotoxin piromen (4-40 ng in 1 microliter) into the anterior hypothalamus were assessed in conscious rats in both sexes from a wide range of body mass and at various ambient temperatures (TaS).(More)
The effects of intracerebroventricular (i.c.v.) injections of sympathomimetic drugs on thermoregulatory functions in conscious rats maintained at low (8 decrees C), moderate (22 degrees C), and high (30 degrees C) ambient temperatures were assessed. Norepinephrine, tyramine, and ephedrine each produced hypothermia at ambient temperature (Ta) 8 degrees C and(More)
Alterations in both physiologic and behavioral functions were assessed in unanesthetized rats after a unilateral injection of kainic acid (KA) in the striatum. The immediate behavioral effects were dyskinesias, head swaying, circling, tail elevation, hyperpnea and marked salivation. The induced behavioral responses lasted for about 14 to 18 h. Rats with(More)
Systemic and central administration of d-amphetamine both produced dose-dependent hypothermia in the rat at ambient temperature (Ta) 8 degrees C. The hypothermia was brought about solely by a decrease in metabolic heat production. However, at both Ta 22 and 30 degrees C, d-amphetamine produced hyperthermia accompanied by behavioral excitation. The(More)
At ambient temperatures (Ta) of both 8 and 22°C, intraventricular administration of TRH (10–80 μg) produced a dose-dependent hypothermia in rats. The hypothermia was due to both decreased metabolic heat production and cutaneous vasodilatation. In contrast, at 30°C Ta, TRH increased metabolic heat production (due to behavioral excitation) and led to(More)