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Three oximes currently being evaluated for adoption as replacement nerve agent therapy by various countries were compared for therapeutic efficacy against the toxic organophosphate inhibitors soman and tabun under a standard set of conditions. These oximes together with PAM-Cl and toxogonin, were also compared for efficacy against GF, an agent weaponized by(More)
The protective ratio produced by HI-6 (with atropine) against soman and tabun poisoning in rats and guinea pigs was determined. The amount of protection afforded by HI-6 decreased with time following poisoning, prompting us to examine the effects of repeated doses of HI-6 (four additional) given over a 5-hr period. In addition, it was determined that HI-6(More)
Female rats poisoned with multiple LD50s of soman or tabun have been shown previously to respond to the protective effects of HI-6 more positively than male rats. This present study was designed first to determine the distribution pattern and concentration of [14C] HI-6 in rats, and secondly, to determine the possibility that HI-6 might be located in high(More)
The acute toxicity of soman was assessed in eight strains of mice (ALAS, CD-1, C57BL, CF1, CFW, C3H, DBA and BALB/c). In fasted animals the LD50 values for soman varied from 98 micrograms/kg in C57BL mice to 151 micrograms/kg in BALB/c mice. In general in non-fasted mice the soman LD50 was not significantly changed except in ALAS strain where the soman LD50(More)
Extracellular ATP is a broad-spectrum cytotoxic agent that produces effects via cell surface P2 purinoceptors. The ligand-gated P2X purinoceptor subtype has very high sequence homology with the RP-2 gene, which encodes for apoptosis. The P2X RNA found in rat vas deferens is expressed preferentially by apoptotic thymocytes. P2X purinoceptor-mediated phasic(More)
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